Ülke: Kanada
Dil: İngilizce
Kaynak: Health Canada
PHENYLEPHRINE HYDROCHLORIDE
LABORATOIRE AGUETTANT
C01CA06
PHENYLEPHRINE
50MCG
SOLUTION
PHENYLEPHRINE HYDROCHLORIDE 50MCG
INTRAVENOUS
10X10ML
Ethical
ALPHA-ADRENERGIC AGONISTS
Active ingredient group (AIG) number: 0100662011; AHFS:
APPROVED
2016-05-04
PRESCRIBING INFORMATION PHENYLEPHRINE HYDROCHLORIDE INJECTION 500 MCG / 10 ML (50 mcg/mL) Vasopressor Intravenous (i.v.) PHYSICIANS SHOULD COMPLETELY FAMILIARIZE THEMSELVES WITH THE COMPLETE CONTENTS OF THIS LEAFLET BEFORE PRESCRIBING THIS DRUG. DESCRIPTION PHENYLEPHRINE HYDROCHLORIDE INJECTION is a vasoconstrictor and pressor drug chemically related to epinephrine and ephedrine. PHARMACOLOGY When applied topically or infiltrated into the tissues, phenylephrine produces vasoconstriction that lasts longer than that of epinephrine and ephedrine. Phenylephrine is a post-synaptic alpha-receptor agonist with little effect on the beta receptors of the heart. Following its intravenous administration, increases in systolic and diastolic blood pressure, and total peripheral vascular resistance are observed rapidly, typically within minutes following i.v. bolus administration. As blood pressure increases, vagal activity also increases, resulting in reflex bradycardia. INDICATIONS For the treatment of clinically important hypotensive states, including overcoming peripheral vascular failure (shock or shock-like states), maintenance of blood pressure in the setting of anesthesia, drug-induced hypotension, or hypersensitivity with circulatory compromise. CONTRAINDICATION Contraindicated in patients with hypertension or ventricular tachycardia or in patients who are hypersensitive to the drug. PRECAUTIONS Should be used with extreme caution in elderly patients or those with hyperthyroidism, bradycardia, partial heart block, myocardial disease or severe arteriosclerosis. Vasopressors may cause serious cardiac arrhythmias during halothane anesthesia and therefore should be used only with great caution or not at all. OXYTOCICS: In obstetrics, if vasopressor drugs are either used to correct hypotension or added to the local anesthetic solution, the obstetrician should be warned that some oxytocic drugs may cause severe persistent hypertension and that even a rupture of a cerebral blood vessel may occur during the postpartum period. Belgenin tamamını okuyun