PHENYLEPHRINE HYDROCHLORIDE INJECTION SOLUTION

Pays: Canada

Langue: anglais

Source: Health Canada

Ingrédients actifs:

PHENYLEPHRINE HYDROCHLORIDE

Disponible depuis:

LABORATOIRE AGUETTANT

Code ATC:

C01CA06

DCI (Dénomination commune internationale):

PHENYLEPHRINE

Dosage:

50MCG

forme pharmaceutique:

SOLUTION

Composition:

PHENYLEPHRINE HYDROCHLORIDE 50MCG

Mode d'administration:

INTRAVENOUS

Unités en paquet:

10X10ML

Type d'ordonnance:

Ethical

Domaine thérapeutique:

ALPHA-ADRENERGIC AGONISTS

Descriptif du produit:

Active ingredient group (AIG) number: 0100662011; AHFS:

Statut de autorisation:

APPROVED

Date de l'autorisation:

2016-05-04

Résumé des caractéristiques du produit

PRESCRIBING INFORMATION
PHENYLEPHRINE HYDROCHLORIDE INJECTION
500 MCG / 10 ML
(50 mcg/mL)
Vasopressor
Intravenous (i.v.)
PHYSICIANS SHOULD COMPLETELY FAMILIARIZE THEMSELVES WITH THE COMPLETE
CONTENTS OF THIS LEAFLET BEFORE PRESCRIBING THIS DRUG.
DESCRIPTION
PHENYLEPHRINE HYDROCHLORIDE INJECTION is a vasoconstrictor and pressor
drug chemically related
to epinephrine and ephedrine.
PHARMACOLOGY
When applied topically or infiltrated into the tissues, phenylephrine
produces vasoconstriction that lasts longer
than that of epinephrine and ephedrine. Phenylephrine is a
post-synaptic alpha-receptor agonist with little effect
on the beta receptors of the heart. Following its intravenous
administration, increases in systolic and diastolic
blood pressure, and total peripheral vascular resistance are observed
rapidly, typically within minutes following
i.v. bolus administration. As blood pressure increases, vagal activity
also increases, resulting in reflex
bradycardia.
INDICATIONS
For the treatment of clinically important hypotensive states,
including overcoming peripheral vascular failure
(shock or shock-like states), maintenance of blood pressure in the
setting of anesthesia, drug-induced
hypotension, or hypersensitivity with circulatory compromise.
CONTRAINDICATION
Contraindicated in patients with hypertension or ventricular
tachycardia or in patients who are hypersensitive to
the drug.
PRECAUTIONS
Should be used with extreme caution in elderly patients or those with
hyperthyroidism, bradycardia, partial heart
block, myocardial disease or severe arteriosclerosis.
Vasopressors may cause serious cardiac arrhythmias during halothane
anesthesia and therefore should be used
only with great caution or not at all.
OXYTOCICS: In obstetrics, if vasopressor drugs are either used to
correct hypotension or added to the local
anesthetic solution, the obstetrician should be warned that some
oxytocic drugs may cause severe persistent
hypertension and that even a rupture of a cerebral blood vessel may
occur during the postpartum period.