PHENYLEPHRINE HYDROCHLORIDE INJECTION SOLUTION

البلد: كندا

اللغة: الإنجليزية

المصدر: Health Canada

العنصر النشط:

PHENYLEPHRINE HYDROCHLORIDE

متاح من:

LABORATOIRE AGUETTANT

ATC رمز:

C01CA06

INN (الاسم الدولي):

PHENYLEPHRINE

جرعة:

50MCG

الشكل الصيدلاني:

SOLUTION

تركيب:

PHENYLEPHRINE HYDROCHLORIDE 50MCG

طريقة التعاطي:

INTRAVENOUS

الوحدات في الحزمة:

10X10ML

نوع الوصفة الطبية :

Ethical

المجال العلاجي:

ALPHA-ADRENERGIC AGONISTS

ملخص المنتج:

Active ingredient group (AIG) number: 0100662011; AHFS:

الوضع إذن:

APPROVED

تاريخ الترخيص:

2016-05-04

خصائص المنتج

PRESCRIBING INFORMATION
PHENYLEPHRINE HYDROCHLORIDE INJECTION
500 MCG / 10 ML
(50 mcg/mL)
Vasopressor
Intravenous (i.v.)
PHYSICIANS SHOULD COMPLETELY FAMILIARIZE THEMSELVES WITH THE COMPLETE
CONTENTS OF THIS LEAFLET BEFORE PRESCRIBING THIS DRUG.
DESCRIPTION
PHENYLEPHRINE HYDROCHLORIDE INJECTION is a vasoconstrictor and pressor
drug chemically related
to epinephrine and ephedrine.
PHARMACOLOGY
When applied topically or infiltrated into the tissues, phenylephrine
produces vasoconstriction that lasts longer
than that of epinephrine and ephedrine. Phenylephrine is a
post-synaptic alpha-receptor agonist with little effect
on the beta receptors of the heart. Following its intravenous
administration, increases in systolic and diastolic
blood pressure, and total peripheral vascular resistance are observed
rapidly, typically within minutes following
i.v. bolus administration. As blood pressure increases, vagal activity
also increases, resulting in reflex
bradycardia.
INDICATIONS
For the treatment of clinically important hypotensive states,
including overcoming peripheral vascular failure
(shock or shock-like states), maintenance of blood pressure in the
setting of anesthesia, drug-induced
hypotension, or hypersensitivity with circulatory compromise.
CONTRAINDICATION
Contraindicated in patients with hypertension or ventricular
tachycardia or in patients who are hypersensitive to
the drug.
PRECAUTIONS
Should be used with extreme caution in elderly patients or those with
hyperthyroidism, bradycardia, partial heart
block, myocardial disease or severe arteriosclerosis.
Vasopressors may cause serious cardiac arrhythmias during halothane
anesthesia and therefore should be used
only with great caution or not at all.
OXYTOCICS: In obstetrics, if vasopressor drugs are either used to
correct hypotension or added to the local
anesthetic solution, the obstetrician should be warned that some
oxytocic drugs may cause severe persistent
hypertension and that even a rupture of a cerebral blood vessel may
occur during the postpartum period.