PHENYLEPHRINE HYDROCHLORIDE INJECTION SOLUTION

Negara: Kanada

Bahasa: Inggris

Sumber: Health Canada

Bahan aktif:

PHENYLEPHRINE HYDROCHLORIDE

Tersedia dari:

LABORATOIRE AGUETTANT

Kode ATC:

C01CA06

INN (Nama Internasional):

PHENYLEPHRINE

Dosis:

50MCG

Bentuk farmasi:

SOLUTION

Komposisi:

PHENYLEPHRINE HYDROCHLORIDE 50MCG

Rute administrasi :

INTRAVENOUS

Unit dalam paket:

10X10ML

Jenis Resep:

Ethical

Area terapi:

ALPHA-ADRENERGIC AGONISTS

Ringkasan produk:

Active ingredient group (AIG) number: 0100662011; AHFS:

Status otorisasi:

APPROVED

Tanggal Otorisasi:

2016-05-04

Karakteristik produk

PRESCRIBING INFORMATION
PHENYLEPHRINE HYDROCHLORIDE INJECTION
500 MCG / 10 ML
(50 mcg/mL)
Vasopressor
Intravenous (i.v.)
PHYSICIANS SHOULD COMPLETELY FAMILIARIZE THEMSELVES WITH THE COMPLETE
CONTENTS OF THIS LEAFLET BEFORE PRESCRIBING THIS DRUG.
DESCRIPTION
PHENYLEPHRINE HYDROCHLORIDE INJECTION is a vasoconstrictor and pressor
drug chemically related
to epinephrine and ephedrine.
PHARMACOLOGY
When applied topically or infiltrated into the tissues, phenylephrine
produces vasoconstriction that lasts longer
than that of epinephrine and ephedrine. Phenylephrine is a
post-synaptic alpha-receptor agonist with little effect
on the beta receptors of the heart. Following its intravenous
administration, increases in systolic and diastolic
blood pressure, and total peripheral vascular resistance are observed
rapidly, typically within minutes following
i.v. bolus administration. As blood pressure increases, vagal activity
also increases, resulting in reflex
bradycardia.
INDICATIONS
For the treatment of clinically important hypotensive states,
including overcoming peripheral vascular failure
(shock or shock-like states), maintenance of blood pressure in the
setting of anesthesia, drug-induced
hypotension, or hypersensitivity with circulatory compromise.
CONTRAINDICATION
Contraindicated in patients with hypertension or ventricular
tachycardia or in patients who are hypersensitive to
the drug.
PRECAUTIONS
Should be used with extreme caution in elderly patients or those with
hyperthyroidism, bradycardia, partial heart
block, myocardial disease or severe arteriosclerosis.
Vasopressors may cause serious cardiac arrhythmias during halothane
anesthesia and therefore should be used
only with great caution or not at all.
OXYTOCICS: In obstetrics, if vasopressor drugs are either used to
correct hypotension or added to the local
anesthetic solution, the obstetrician should be warned that some
oxytocic drugs may cause severe persistent
hypertension and that even a rupture of a cerebral blood vessel may
occur during the postpartum period.