SUCCINYLCHOLINE CHLORIDE INJECTION, USP SOLUTION

国: カナダ

言語: 英語

ソース: Health Canada

有効成分:

SUCCINYLCHOLINE CHLORIDE

から入手可能:

DR REDDY'S LABORATORIES LTD

ATCコード:

M03AB01

INN（国際名）:

SUXAMETHONIUM

投薬量:

20MG

医薬品形態:

SOLUTION

構図:

SUCCINYLCHOLINE CHLORIDE 20MG

投与経路:

INTRAVENOUS

パッケージ内のユニット:

15G/50G

処方タイプ:

Prescription

治療領域:

NEUROMUSCULAR BLOCKING AGENTS

製品概要:

Active ingredient group (AIG) number: 0105141001; AHFS:

認証ステータス:

APPROVED

承認日:

2020-07-08

製品の特徴

1
PRESCRIBING INFORMATION
PR
SUCCINYLCHOLINE CHLORIDE INJECTION, USP
200 mg / 10 mL (20 mg / mL)
Sterile Solution
NEUROMUSCULAR BLOCKING AGENT
Manufactured by:
DR. REDDY’S LABORATORIES LTD.,
Bachupally – 500 090
India
Imported and Distributed by:
DR. REDDY’S LABORATORIES CANADA INC.,
Mississauga, ON L4W 4Y1
Canada
Date of Revision:
January 16, 2023
Submission Control Number: 264137
2
PRESCRIBING INFORMATION
PR
SUCCINYLCHOLINE CHLORIDE INJECTION, USP
200 mg / 10 mL (20 mg / mL)
Sterile Solution
Neuromuscular Blocking Agent
ACTION AND CLINICAL PHARMACOLOGY
Succinylcholine is an ultra short-acting, depolarizing-type, skeletal
muscle relaxant. As does
acetylcholine, it combines with the cholinergic receptors of the motor
end plate to produce
depolarization. This depolarization may be observed as fasciculations.
Subsequent neuromuscular
transmission is inhibited so long as adequate concentration of
succinylcholine remains at the
receptor site. Onset of flaccid paralysis is rapid (less than one
minute after i.v. administration), and
with single administration lasts approximately 4 to 6 minutes.
Succinylcholine is rapidly hydrolysed by plasma cholinesterase to
succinylmonocholine (which
possesses clinically insignificant depolarizing muscle relaxant
properties) and then more slowly to
succinic acid and choline (see PRECAUTIONS). About 10% of the drug is
excreted unchanged in
the urine. The paralysis following administration of succinylcholine
chloride is progressive,
initially involving consecutively the levator muscles of the face,
muscles of the glottis and finally
the intercostals and the diaphragm and all other skeletal muscles.
Succinylcholine has no direct action on the uterus or other smooth
muscle structures. Because it is
highly ionized and has low fat solubility, it does not readily cross
the placenta.
Tachyphylaxis occurs with repeated administration (see PRECAUTIONS).
Depending on the dose and duration of succinylcholine administration,
the characteristic
depolarizing neuromuscular block (Phase I block