SUCCINYLCHOLINE CHLORIDE INJECTION, USP SOLUTION

국가: 캐나다

언어: 영어

출처: Health Canada

유효 성분:

SUCCINYLCHOLINE CHLORIDE

제공처:

DR REDDY'S LABORATORIES LTD

ATC 코드:

M03AB01

INN (International Name):

SUXAMETHONIUM

복용량:

20MG

약제 형태:

SOLUTION

구성:

SUCCINYLCHOLINE CHLORIDE 20MG

관리 경로:

INTRAVENOUS

패키지 단위:

15G/50G

처방전 유형:

Prescription

치료 영역:

NEUROMUSCULAR BLOCKING AGENTS

제품 요약:

Active ingredient group (AIG) number: 0105141001; AHFS:

승인 상태:

APPROVED

승인 날짜:

2020-07-08

제품 특성 요약

1
PRESCRIBING INFORMATION
PR
SUCCINYLCHOLINE CHLORIDE INJECTION, USP
200 mg / 10 mL (20 mg / mL)
Sterile Solution
NEUROMUSCULAR BLOCKING AGENT
Manufactured by:
DR. REDDY’S LABORATORIES LTD.,
Bachupally – 500 090
India
Imported and Distributed by:
DR. REDDY’S LABORATORIES CANADA INC.,
Mississauga, ON L4W 4Y1
Canada
Date of Revision:
January 16, 2023
Submission Control Number: 264137
2
PRESCRIBING INFORMATION
PR
SUCCINYLCHOLINE CHLORIDE INJECTION, USP
200 mg / 10 mL (20 mg / mL)
Sterile Solution
Neuromuscular Blocking Agent
ACTION AND CLINICAL PHARMACOLOGY
Succinylcholine is an ultra short-acting, depolarizing-type, skeletal
muscle relaxant. As does
acetylcholine, it combines with the cholinergic receptors of the motor
end plate to produce
depolarization. This depolarization may be observed as fasciculations.
Subsequent neuromuscular
transmission is inhibited so long as adequate concentration of
succinylcholine remains at the
receptor site. Onset of flaccid paralysis is rapid (less than one
minute after i.v. administration), and
with single administration lasts approximately 4 to 6 minutes.
Succinylcholine is rapidly hydrolysed by plasma cholinesterase to
succinylmonocholine (which
possesses clinically insignificant depolarizing muscle relaxant
properties) and then more slowly to
succinic acid and choline (see PRECAUTIONS). About 10% of the drug is
excreted unchanged in
the urine. The paralysis following administration of succinylcholine
chloride is progressive,
initially involving consecutively the levator muscles of the face,
muscles of the glottis and finally
the intercostals and the diaphragm and all other skeletal muscles.
Succinylcholine has no direct action on the uterus or other smooth
muscle structures. Because it is
highly ionized and has low fat solubility, it does not readily cross
the placenta.
Tachyphylaxis occurs with repeated administration (see PRECAUTIONS).
Depending on the dose and duration of succinylcholine administration,
the characteristic
depolarizing neuromuscular block (Phase I block