SUCCINYLCHOLINE CHLORIDE INJECTION, USP SOLUTION

Krajina: Kanada

Jazyk: angličtina

Zdroj: Health Canada

Aktívna zložka:

SUCCINYLCHOLINE CHLORIDE

Dostupné z:

DR REDDY'S LABORATORIES LTD

ATC kód:

M03AB01

INN (Medzinárodný Name):

SUXAMETHONIUM

Dávkovanie:

20MG

Forma lieku:

SOLUTION

Zloženie:

SUCCINYLCHOLINE CHLORIDE 20MG

Spôsob podávania:

INTRAVENOUS

Počet v balení:

15G/50G

Typ predpisu:

Prescription

Terapeutické oblasti:

NEUROMUSCULAR BLOCKING AGENTS

Prehľad produktov:

Active ingredient group (AIG) number: 0105141001; AHFS:

Stav Autorizácia:

APPROVED

Dátum Autorizácia:

2020-07-08

Súhrn charakteristických

1
PRESCRIBING INFORMATION
PR
SUCCINYLCHOLINE CHLORIDE INJECTION, USP
200 mg / 10 mL (20 mg / mL)
Sterile Solution
NEUROMUSCULAR BLOCKING AGENT
Manufactured by:
DR. REDDY’S LABORATORIES LTD.,
Bachupally – 500 090
India
Imported and Distributed by:
DR. REDDY’S LABORATORIES CANADA INC.,
Mississauga, ON L4W 4Y1
Canada
Date of Revision:
January 16, 2023
Submission Control Number: 264137
2
PRESCRIBING INFORMATION
PR
SUCCINYLCHOLINE CHLORIDE INJECTION, USP
200 mg / 10 mL (20 mg / mL)
Sterile Solution
Neuromuscular Blocking Agent
ACTION AND CLINICAL PHARMACOLOGY
Succinylcholine is an ultra short-acting, depolarizing-type, skeletal
muscle relaxant. As does
acetylcholine, it combines with the cholinergic receptors of the motor
end plate to produce
depolarization. This depolarization may be observed as fasciculations.
Subsequent neuromuscular
transmission is inhibited so long as adequate concentration of
succinylcholine remains at the
receptor site. Onset of flaccid paralysis is rapid (less than one
minute after i.v. administration), and
with single administration lasts approximately 4 to 6 minutes.
Succinylcholine is rapidly hydrolysed by plasma cholinesterase to
succinylmonocholine (which
possesses clinically insignificant depolarizing muscle relaxant
properties) and then more slowly to
succinic acid and choline (see PRECAUTIONS). About 10% of the drug is
excreted unchanged in
the urine. The paralysis following administration of succinylcholine
chloride is progressive,
initially involving consecutively the levator muscles of the face,
muscles of the glottis and finally
the intercostals and the diaphragm and all other skeletal muscles.
Succinylcholine has no direct action on the uterus or other smooth
muscle structures. Because it is
highly ionized and has low fat solubility, it does not readily cross
the placenta.
Tachyphylaxis occurs with repeated administration (see PRECAUTIONS).
Depending on the dose and duration of succinylcholine administration,
the characteristic
depolarizing neuromuscular block (Phase I block