情報リーフレット
OCTREOTIDE-MAXRX INJECTION
(MAX PHARMA)
CONSUMER MEDICINE
INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Octreotide-MaxRx Injection.
It does not contain all the available
information. It does not take the place of
talking to your doctor or pharmacist.
All medicines have risks and benefits. Your
doctor has weighed the risks of you using
Octreotide-MaxRx Injection against the
benefits they expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT USING
THIS MEDICINE, ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT OCTREOTIDE-MAXRX INJECTION IS
USED FOR
Octreotide-MaxRx Injection has three uses:
1. Octreotide-MaxRx Injection is used to
treat acromegaly.
In people with acromegaly the body
makes too much growth hormone, which
controls the growth of tissues, organs
and bones. This leads to enlargement of
the bones, especially of the hands and
feet. Other symptoms include headaches,
increased sweating, tiredness,
numbness of the hands and feet, pain
and stiffness in the joints and loss of
sexual function. By blocking the excess
growth hormone, Octreotide-MaxRx
Injection can relieve many of these
symptoms.
2. Octreotide-MaxRx Injection is used to
relieve symptoms of certain types of
cancer such as carcinoid syndrome and
VIPoma.
By blocking hormones that are over-
produced in these conditions, Octreotide-
MaxRx Injection can relieve symptoms
such as flushing of the skin and severe
diarrhoea.
3. Octreotide-MaxRx Injection is used for
people who are having surgery on the
pancreas. This medicine helps to lower
the chance of complications after the
surgery.
Octreotide-MaxRx Injection contains
octreotide, a man-made medicine derived
from somatostatin, a substance found in the
human body. Octreotide is used instead of
somatostatin because its effects are
stronger and last longer so that it
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製品の特徴
OCTREOTIDE-MAXRX INJECTION
(MAX PHARMA)
COMPOSITION
Octreotide
_ _
_Chemical name: _D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-
N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2
7) - disulphide
DESCRIPTION
Octreotide is a synthetic octapeptide analogue of somatostatin.
where x = 1.4 to 2.5
CAS number: 79517-01-4. (octreotide acetate)
MW: 1019.3 (free peptide)
Each 1 mL ampoule contains 0.05 mg, 0.1 mg or 0.5 mg octreotide (present as acetate). The
solution is clear and colourless.
Excipients: glycine, mannitol, hydrochloric acid, water for injections.
PHARMACOLOGY
_ _
_PHARMACODYNAMICS: _
Octreotide is a synthetic octapeptide analogue of naturally occurring somatostatin with similar
pharmacological effects, but with a considerably prolonged duration of action. It inhibits the
secretion of serotonin and the gastro-entero-pancreatic peptides: gastrin, vasoactive intestinal
peptide, insulin, glucagon, secretin, motilin, and pancreatic polypeptide, and of growth hormone
(GH). Octreotide, like somatostatin, decreases splanchnic blood flow.
_Octreotide-MaxRx Injection _
_Max Pharma Pty Ltd _
_Product Information v2 _
Page 2 of 11
In animals, octreotide is a more potent inhibitor of growth hormone, glucagon and insulin release
than somatostatin with greater selectivity for GH- and glucagon-suppression.
In healthy subjects octreotide, like somatostatin, has been shown to inhibit:
release of growth hormone (GH) stimulated by arginine, exercise and insulin-induced
hypoglycaemia
postprandial release of insulin, glucagon, gastrin, other peptides of the GEP system, and
arginine-stimulated release of insulin and glucagon
thyrotropin releasing hormone (TRH) stimulated releas
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