Land: Australië
Taal: Engels
Bron: Department of Health (Therapeutic Goods Administration)
Octreotide
Generic Health Pty Ltd
Medicine Registered
OCTREOTIDE-MAXRX INJECTION (MAX PHARMA) CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Octreotide-MaxRx Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using Octreotide-MaxRx Injection against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT USING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT OCTREOTIDE-MAXRX INJECTION IS USED FOR Octreotide-MaxRx Injection has three uses: 1. Octreotide-MaxRx Injection is used to treat acromegaly. In people with acromegaly the body makes too much growth hormone, which controls the growth of tissues, organs and bones. This leads to enlargement of the bones, especially of the hands and feet. Other symptoms include headaches, increased sweating, tiredness, numbness of the hands and feet, pain and stiffness in the joints and loss of sexual function. By blocking the excess growth hormone, Octreotide-MaxRx Injection can relieve many of these symptoms. 2. Octreotide-MaxRx Injection is used to relieve symptoms of certain types of cancer such as carcinoid syndrome and VIPoma. By blocking hormones that are over- produced in these conditions, Octreotide- MaxRx Injection can relieve symptoms such as flushing of the skin and severe diarrhoea. 3. Octreotide-MaxRx Injection is used for people who are having surgery on the pancreas. This medicine helps to lower the chance of complications after the surgery. Octreotide-MaxRx Injection contains octreotide, a man-made medicine derived from somatostatin, a substance found in the human body. Octreotide is used instead of somatostatin because its effects are stronger and last longer so that it Lees het volledige document
OCTREOTIDE-MAXRX INJECTION (MAX PHARMA) COMPOSITION Octreotide _ _ _Chemical name: _D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl- N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2 7) - disulphide DESCRIPTION Octreotide is a synthetic octapeptide analogue of somatostatin. where x = 1.4 to 2.5 CAS number: 79517-01-4. (octreotide acetate) MW: 1019.3 (free peptide) Each 1 mL ampoule contains 0.05 mg, 0.1 mg or 0.5 mg octreotide (present as acetate). The solution is clear and colourless. Excipients: glycine, mannitol, hydrochloric acid, water for injections. PHARMACOLOGY _ _ _PHARMACODYNAMICS: _ Octreotide is a synthetic octapeptide analogue of naturally occurring somatostatin with similar pharmacological effects, but with a considerably prolonged duration of action. It inhibits the secretion of serotonin and the gastro-entero-pancreatic peptides: gastrin, vasoactive intestinal peptide, insulin, glucagon, secretin, motilin, and pancreatic polypeptide, and of growth hormone (GH). Octreotide, like somatostatin, decreases splanchnic blood flow. _Octreotide-MaxRx Injection _ _Max Pharma Pty Ltd _ _Product Information v2 _ Page 2 of 11 In animals, octreotide is a more potent inhibitor of growth hormone, glucagon and insulin release than somatostatin with greater selectivity for GH- and glucagon-suppression. In healthy subjects octreotide, like somatostatin, has been shown to inhibit: release of growth hormone (GH) stimulated by arginine, exercise and insulin-induced hypoglycaemia postprandial release of insulin, glucagon, gastrin, other peptides of the GEP system, and arginine-stimulated release of insulin and glucagon thyrotropin releasing hormone (TRH) stimulated releas Lees het volledige document