OCTREOTIDE-MAXRX

Valsts: Austrālija

Valoda: angļu

Klimata pārmaiņas: Department of Health (Therapeutic Goods Administration)

Aktīvā sastāvdaļa:

Octreotide

Pieejams no:

Generic Health Pty Ltd

Klase:

Medicine Registered

Lietošanas instrukcija

OCTREOTIDE-MAXRX INJECTION
(MAX PHARMA)
CONSUMER MEDICINE 
INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common 
questions about Octreotide-MaxRx Injection. 
It does not contain all the available 
information. It does not take the place of 
talking to your doctor or pharmacist. 
All medicines have risks and benefits. Your 
doctor has weighed the risks of you using 
Octreotide-MaxRx Injection against the 
benefits they expect it will have for you. 
IF YOU HAVE ANY CONCERNS ABOUT USING 
THIS MEDICINE, ASK YOUR DOCTOR OR 
PHARMACIST. 
KEEP THIS LEAFLET WITH THE MEDICINE. 
You may need to read it again. 
WHAT OCTREOTIDE-MAXRX INJECTION IS 
USED FOR
Octreotide-MaxRx Injection has three uses: 
1. Octreotide-MaxRx Injection is used to 
treat acromegaly.
In people with acromegaly the body 
makes too much growth hormone, which 
controls the growth of tissues, organs 
and bones. This leads to enlargement of 
the bones, especially of the hands and 
feet. Other symptoms include headaches, 
increased sweating, tiredness, 
numbness of the hands and feet, pain 
and stiffness in the joints and loss of 
sexual function. By blocking the excess 
growth hormone, Octreotide-MaxRx
Injection can relieve many of these 
symptoms. 
2. Octreotide-MaxRx Injection is used to 
relieve symptoms of certain types of 
cancer such as carcinoid syndrome and 
VIPoma. 
By blocking hormones that are over-
produced in these conditions, Octreotide-
MaxRx Injection can relieve symptoms 
such as flushing of the skin and severe 
diarrhoea. 
3. Octreotide-MaxRx Injection is used for 
people who are having surgery on the 
pancreas. This medicine helps to lower 
the chance of complications after the 
surgery. 
Octreotide-MaxRx Injection contains 
octreotide, a man-made medicine derived 
from somatostatin, a substance found in the 
human body. Octreotide is used instead of 
somatostatin because its effects are 
stronger and last longer so that it

Produkta apraksts

OCTREOTIDE-MAXRX INJECTION 
(MAX PHARMA) 

COMPOSITION 

Octreotide 
_ _
_Chemical name: _D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-
N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2

7) - disulphide 

DESCRIPTION 

Octreotide is a synthetic octapeptide analogue of somatostatin. 

where x = 1.4 to 2.5 

CAS number: 79517-01-4. (octreotide acetate) 
MW: 1019.3 (free peptide)  

Each 1 mL ampoule contains 0.05 mg, 0.1 mg or 0.5 mg octreotide (present as acetate). The 
solution is clear and colourless. 

Excipients: glycine, mannitol, hydrochloric acid, water for injections. 

PHARMACOLOGY 
_ _
_PHARMACODYNAMICS: _

Octreotide is a synthetic octapeptide analogue of naturally occurring somatostatin with similar 
pharmacological effects, but with a considerably prolonged duration of action. It inhibits the 
secretion of serotonin and the gastro-entero-pancreatic peptides: gastrin, vasoactive intestinal 
peptide, insulin, glucagon, secretin, motilin, and pancreatic polypeptide, and of growth hormone 
(GH). Octreotide, like somatostatin, decreases splanchnic blood flow.  
_Octreotide-MaxRx Injection _
_Max Pharma Pty Ltd _
_Product Information v2 _
Page 2 of 11 

In animals, octreotide is a more potent inhibitor of growth hormone, glucagon and insulin release 
than somatostatin with greater selectivity for GH- and glucagon-suppression. 

In healthy subjects octreotide, like somatostatin, has been shown to inhibit: 

  release of growth hormone (GH) stimulated by arginine, exercise and insulin-induced 
hypoglycaemia 

  postprandial release of insulin, glucagon, gastrin, other peptides of the GEP system, and 
arginine-stimulated release of insulin and glucagon 

  thyrotropin releasing hormone (TRH) stimulated releas