资料单张
BAXTER CARBOPLATIN (carboplatin)
Consumer Medicine Information
BAXTER CARBOPLATIN CMI 080818
Page 1 of 5
Baxter
BAXTER CARBOPLATIN
_Carboplatin _
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about
Carboplatin Injection.
It does not contain all the
available information.
It does not take the place of
talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has
weighed the risks of you taking
Carboplatin Injection against the
benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS
ABOUT TAKING THIS MEDICINE,
ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET IN A SAFE
PLACE.
You may need to read it again.
WHAT CARBOPLATIN INJECTION IS
USED FOR
Carboplatin Injection is used to
treat various types of cancer,
such as: _ _
cancer of the testes
ovarian cancer
a type of cancer called
sarcoma
cancer of the brain and/or
spinal cord
some types of lung cancer
cancer of the head and neck
neuroblastoma, a cancer of
nerves and the adrenal
glands.
Carboplatin Injection belongs to
a group of medicines called
antineoplastic or cytotoxic
medicines. You may also hear
of these being called
chemotherapy medicines.
Carboplatin belongs to the group
of anticancer medicines called
the platinum complexes.
Carboplatin Injection works by
killing cancer cells and/or
stopping cancer cells from
growing and multiplying.
Carboplatin Injection is often
used in combination with other
medicines to treat cancer.
Your doctor may have
prescribed Carboplatin Injection
for another reason.
ASK YOUR DOCTOR IF YOU HAVE
ANY QUESTIONS ABOUT WHY
CARBOPLATIN INJECTION HAS
BEEN PRESCRIBED FOR YOU.
Carboplatin Injection is not
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产品特点
BAXTER CARBOPLATIN (carboplatin)
Product Information
BAXTER CARBOPLATIN PI Approved 080818
Page 1 of 9
Baxter
BAXTER CARBOPLATIN
NAME OF THE MEDICINE
Carboplatin.
The chemical structure is shown below:
DESCRIPTION
The chemical name of carboplatin is
(SP-4-2)-diamine cyclobutane-1,1-dicarboxylato
(2-)-O, O’platin and the CAS registry number is 41575-94-4.
Carboplatin has a molecular weight of 371.26
and a molecular formula of C
6
H
12
N
2
O
4
Pt.
It is a colourless, crystalline powder, sparingly soluble in water,
very slightly soluble in
acetone and in alcohol.
Carboplatin Injection is a sterile solution of carboplatin in
Water for Injections BP. It is
presented in vials containing 50 mg/ 5 mL, 150 mg/15 mL and 450 mg/
45 mL. The
solution does not contain any preservatives. The pH of the
injection ranges between 5.0
to 7.0.
PHARMACOLOGY
Carboplatin, an analogue of cisplatin, is an antineoplastic agent
which interferes with
DNA intrastrand and interstrand crosslinks in cells exposed to
the drug. DNA reactivity
has been correlated with cytotoxicity.
PHARMACOKINETICS: After a one-hour infusion of
the drug (dose range 20 to 520 mg/m
2
)
plasma levels of total platinum and ultra filterable (free)
platinum decay biphasically
following first order kinetics. For ultra filterable platinum,
reported values for the initial
phase of the half life (t
α½
) are about 90 minutes and in the later phase the half life (t
β½
) is
about 6 hours. Total platinum elimination has a similar initial
half life while in the later
phase the half life of total platinum may be greater than 24
hours. Carboplatin is a stable
molecule. All free platinum is in the form of carboplatin in the
first 4 hours.
65% of the carboplatin dose is eliminated in the urine within 24
hours of administration,
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