BAXTER CARBOPLATIN

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Carboplatin

Available from:

Baxter Healthcare Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

BAXTER CARBOPLATIN (carboplatin) 

Consumer Medicine Information 

BAXTER CARBOPLATIN CMI 080818 

Page 1 of 5 
Baxter 
BAXTER CARBOPLATIN  
_Carboplatin _

WHAT IS IN THIS LEAFLET 

This leaflet answers some 
common questions about 
Carboplatin Injection. 

It does not contain all the 
available information. 

It does not take the place of 
talking to your doctor or 
pharmacist. 

All medicines have risks and 
benefits. Your doctor has 
weighed the risks of you taking 
Carboplatin Injection against the 
benefits they expect it will have 
for you. 

IF YOU HAVE ANY CONCERNS 
ABOUT TAKING THIS MEDICINE, 
ASK YOUR DOCTOR OR 
PHARMACIST. 

KEEP THIS LEAFLET IN A SAFE 
PLACE. 
You may need to read it again. 

WHAT CARBOPLATIN INJECTION IS 
USED FOR 

Carboplatin Injection is used to 
treat various types of cancer, 
such as:  _ _


  cancer of the testes 

  ovarian cancer 

  a type of cancer called 
sarcoma 

  cancer of the brain and/or 
spinal cord  

  some types of lung cancer 

  cancer of the head and neck 

  neuroblastoma, a cancer of 
nerves and the adrenal 
glands. 
Carboplatin Injection belongs to 
a group of medicines called 
antineoplastic or cytotoxic 
medicines.  You may also hear 
of these being called 
chemotherapy medicines. 
Carboplatin belongs to the group 
of anticancer medicines called 
the platinum complexes. 

Carboplatin Injection works by 
killing cancer cells and/or 
stopping cancer cells from 
growing and multiplying. 

Carboplatin Injection is often 
used in combination with other 
medicines to treat cancer. 

Your doctor may have 
prescribed Carboplatin Injection 
for another reason.   

ASK YOUR DOCTOR IF YOU HAVE 
ANY QUESTIONS ABOUT WHY 
CARBOPLATIN INJECTION HAS 
BEEN PRESCRIBED FOR YOU. 

Carboplatin Injection is not 

Summary of Product characteristics

BAXTER CARBOPLATIN (carboplatin) 

Product Information 

BAXTER CARBOPLATIN PI Approved 080818   
Page 1 of 9 
Baxter 

BAXTER CARBOPLATIN  

NAME OF THE MEDICINE 

Carboplatin. 
The chemical structure is shown below: 

DESCRIPTION 

The chemical name of carboplatin is
(SP-4-2)-diamine cyclobutane-1,1-dicarboxylato 
(2-)-O, O’platin and the CAS registry number is 41575-94-4. 

Carboplatin has a molecular weight of 371.26
and a molecular formula of C
6
H
12
 N
2
O
4
Pt. 
It is a colourless, crystalline powder, sparingly soluble in water,
very slightly soluble in 
acetone and in alcohol. 

Carboplatin Injection is a sterile solution of carboplatin in
Water for Injections BP. It is 
presented in vials containing 50 mg/ 5 mL, 150 mg/15 mL and 450 mg/
45 mL. The 
solution does not contain any preservatives. The pH of the
injection ranges between 5.0 
to 7.0.  

PHARMACOLOGY 

Carboplatin, an analogue of cisplatin, is an antineoplastic agent
which interferes with 
DNA intrastrand and interstrand crosslinks in cells exposed to
the drug.  DNA reactivity 
has been correlated with cytotoxicity.  

PHARMACOKINETICS: After a one-hour infusion of
the drug (dose range 20 to 520 mg/m
2
) 
plasma levels of total platinum and ultra filterable (free)
platinum decay biphasically 
following first order kinetics.  For ultra filterable platinum,
reported values for the initial 
phase of the half life (t
α½
) are about 90 minutes and in the later phase the half life (t
β½
) is 
about 6 hours.  Total platinum elimination has a similar initial
half life while in the later 
phase the half life of total platinum may be greater than 24
hours.  Carboplatin is a stable 
molecule.  All free platinum is in the form of carboplatin in the
first 4 hours.  

65% of the carboplatin dose is eliminated in the urine within 24
hours of administration,