देश: ऑस्ट्रेलिया
भाषा: अंग्रेज़ी
स्रोत: Department of Health (Therapeutic Goods Administration)
Carboplatin
Baxter Healthcare Pty Ltd
Medicine Registered
BAXTER CARBOPLATIN (carboplatin) Consumer Medicine Information BAXTER CARBOPLATIN CMI 080818 Page 1 of 5 Baxter BAXTER CARBOPLATIN _Carboplatin _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Carboplatin Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Carboplatin Injection against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET IN A SAFE PLACE. You may need to read it again. WHAT CARBOPLATIN INJECTION IS USED FOR Carboplatin Injection is used to treat various types of cancer, such as: _ _ cancer of the testes ovarian cancer a type of cancer called sarcoma cancer of the brain and/or spinal cord some types of lung cancer cancer of the head and neck neuroblastoma, a cancer of nerves and the adrenal glands. Carboplatin Injection belongs to a group of medicines called antineoplastic or cytotoxic medicines. You may also hear of these being called chemotherapy medicines. Carboplatin belongs to the group of anticancer medicines called the platinum complexes. Carboplatin Injection works by killing cancer cells and/or stopping cancer cells from growing and multiplying. Carboplatin Injection is often used in combination with other medicines to treat cancer. Your doctor may have prescribed Carboplatin Injection for another reason. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY CARBOPLATIN INJECTION HAS BEEN PRESCRIBED FOR YOU. Carboplatin Injection is not पूरा दस्तावेज़ पढ़ें
BAXTER CARBOPLATIN (carboplatin) Product Information BAXTER CARBOPLATIN PI Approved 080818 Page 1 of 9 Baxter BAXTER CARBOPLATIN NAME OF THE MEDICINE Carboplatin. The chemical structure is shown below: DESCRIPTION The chemical name of carboplatin is (SP-4-2)-diamine cyclobutane-1,1-dicarboxylato (2-)-O, O’platin and the CAS registry number is 41575-94-4. Carboplatin has a molecular weight of 371.26 and a molecular formula of C 6 H 12 N 2 O 4 Pt. It is a colourless, crystalline powder, sparingly soluble in water, very slightly soluble in acetone and in alcohol. Carboplatin Injection is a sterile solution of carboplatin in Water for Injections BP. It is presented in vials containing 50 mg/ 5 mL, 150 mg/15 mL and 450 mg/ 45 mL. The solution does not contain any preservatives. The pH of the injection ranges between 5.0 to 7.0. PHARMACOLOGY Carboplatin, an analogue of cisplatin, is an antineoplastic agent which interferes with DNA intrastrand and interstrand crosslinks in cells exposed to the drug. DNA reactivity has been correlated with cytotoxicity. PHARMACOKINETICS: After a one-hour infusion of the drug (dose range 20 to 520 mg/m 2 ) plasma levels of total platinum and ultra filterable (free) platinum decay biphasically following first order kinetics. For ultra filterable platinum, reported values for the initial phase of the half life (t α½ ) are about 90 minutes and in the later phase the half life (t β½ ) is about 6 hours. Total platinum elimination has a similar initial half life while in the later phase the half life of total platinum may be greater than 24 hours. Carboplatin is a stable molecule. All free platinum is in the form of carboplatin in the first 4 hours. 65% of the carboplatin dose is eliminated in the urine within 24 hours of administration, पूरा दस्तावेज़ पढ़ें