资料单张
APO-RAMIPRIL
_contains the active ingredient, ramipril_
CONSUMER MEDICINE INFORMATION
_FOR A COPY OF A LARGE PRINT LEAFLET PH: 1800 195 055_
WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE ASK YOUR
DOCTOR OR PHARMACIST IF YOU DO NOT
UNDERSTAND ANYTHING OR ARE
WORRIED ABOUT TAKING YOUR
MEDICINE.
This leaflet answers some common
questions about ramipril.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. Some more recent
information on your medicine may
be available. Speak to your
pharmacist or doctor to obtain the
most up-to-date information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may want to read it again.
WHAT RAMIPRIL IS USED
FOR
The name of your medicine is APO-
Ramipril. It contains the active
ingredient, ramipril.
Ramipril belongs to a group of
medicines called angiotensin
converting enzyme (ACE) inhibitors.
Ramipril is used to treat:
•
high blood pressure
(hypertension)
•
some heart conditions, such as
heart failure after a heart attack
•
kidney problems in some patients.
Ramipril is also used to reduce the
risk of cardiovascular problems and
complications in patients aged 55
years or more with heart or blood
vessel disease, or diabetes.
HIGH BLOOD PRESSURE
(HYPERTENSION)
Ramipril is used to lower high blood
pressure (hypertension). Everyone
has blood pressure. This pressure
helps get your blood all around your
body. Your blood pressure may be
different at different times of the day
and can be influenced by how busy
or worried you are. You have high
blood pressure when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
high blood pressure. The only way of
knowing that you have hi
阅读完整的文件
产品特点
Product Information – Australia
APO-Ramipril Capsules
Page 1
APO-RAMIPRIL CAPSULES
NAME OF THE MEDICINE
Non-proprietary name: Ramipril
Chemical Name:
(2_S_,3a_S_,6a_S_)-1-[(2_S_)-2-[[(1_S_)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]
propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
Structural Formula:
Ramipril has 5 chiral centres, with S-configuration in
all 5 asymmetric carbon atoms.
Molecular Formula:
C
23
H
32
N
2
O
5
Molecular Weight:
416.51
CAS Registry Number:
87333-19-5
DESCRIPTION
Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid
derivative. It is a white, crystalline
substance sparingly soluble in water and soluble
in polar organic solvents and buffered aqueous
solutions. Ramipril melts between 105°C and 112°C.
PHARMACOLOGY
MECHANISM OF ACTION
Ramipril is a pro-drug which, after absorption from the gastrointestinal tract, is hydrolysed in the liver
to form the active moiety, ramiprilat. Ramipril and
ramiprilat inhibit angiotensin-converting enzyme
(ACE) which is identical to kininase II. This converting
enzyme (ACE) is a peptidyl dipeptidase that
catalyses the conversion of angiotensin I to
the vasoconstrictor substance, angiotensin II. Angiotensin
II also stimulates aldosterone secretion
by the adrenal cortex, thus inhibition of ACE results in
decreased plasma
angiotensin II, which leads to decreased vasopressor activity and to decreased
aldosterone secretion. The latter decrease may result in a
small increase in serum potassium.
Kininase II is one of the enzymes responsible for the
degradation of bradykinin, a potent
vasodepressor peptide. The
inhibition of kininase II activity by ramipril prevents the
degradation of
bradykinin
thus leading to increased levels of this potent vasodepressor substance. While
阅读完整的文件