Quốc gia: Úc
Ngôn ngữ: Tiếng Anh
Nguồn: Department of Health (Therapeutic Goods Administration)
Ramipril
Apotex Pty Ltd
Medicine Registered
APO-RAMIPRIL _contains the active ingredient, ramipril_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE ASK YOUR DOCTOR OR PHARMACIST IF YOU DO NOT UNDERSTAND ANYTHING OR ARE WORRIED ABOUT TAKING YOUR MEDICINE. This leaflet answers some common questions about ramipril. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. Some more recent information on your medicine may be available. Speak to your pharmacist or doctor to obtain the most up-to-date information. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may want to read it again. WHAT RAMIPRIL IS USED FOR The name of your medicine is APO- Ramipril. It contains the active ingredient, ramipril. Ramipril belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. Ramipril is used to treat: • high blood pressure (hypertension) • some heart conditions, such as heart failure after a heart attack • kidney problems in some patients. Ramipril is also used to reduce the risk of cardiovascular problems and complications in patients aged 55 years or more with heart or blood vessel disease, or diabetes. HIGH BLOOD PRESSURE (HYPERTENSION) Ramipril is used to lower high blood pressure (hypertension). Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day and can be influenced by how busy or worried you are. You have high blood pressure when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are usually no symptoms of high blood pressure. The only way of knowing that you have hi Đọc toàn bộ tài liệu
Product Information – Australia APO-Ramipril Capsules Page 1 APO-RAMIPRIL CAPSULES NAME OF THE MEDICINE Non-proprietary name: Ramipril Chemical Name: (2_S_,3a_S_,6a_S_)-1-[(2_S_)-2-[[(1_S_)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino] propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid Structural Formula: Ramipril has 5 chiral centres, with S-configuration in all 5 asymmetric carbon atoms. Molecular Formula: C 23 H 32 N 2 O 5 Molecular Weight: 416.51 CAS Registry Number: 87333-19-5 DESCRIPTION Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance sparingly soluble in water and soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°C and 112°C. PHARMACOLOGY MECHANISM OF ACTION Ramipril is a pro-drug which, after absorption from the gastrointestinal tract, is hydrolysed in the liver to form the active moiety, ramiprilat. Ramipril and ramiprilat inhibit angiotensin-converting enzyme (ACE) which is identical to kininase II. This converting enzyme (ACE) is a peptidyl dipeptidase that catalyses the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex, thus inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion. The latter decrease may result in a small increase in serum potassium. Kininase II is one of the enzymes responsible for the degradation of bradykinin, a potent vasodepressor peptide. The inhibition of kininase II activity by ramipril prevents the degradation of bradykinin thus leading to increased levels of this potent vasodepressor substance. While Đọc toàn bộ tài liệu