APO-Ramipril Capsules

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Ramipril

Available from:

Apotex Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

APO-RAMIPRIL

_contains the active ingredient, ramipril_
CONSUMER MEDICINE INFORMATION

_FOR A COPY OF A LARGE PRINT LEAFLET PH: 1800 195 055_

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE ASK YOUR
DOCTOR OR PHARMACIST IF YOU DO NOT
UNDERSTAND ANYTHING OR ARE
WORRIED ABOUT TAKING YOUR
MEDICINE.
This leaflet answers some common
questions about ramipril.
It does not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. Some more recent
information on your medicine may
be available. Speak to your
pharmacist or doctor to obtain the
most up-to-date information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may want to read it again.
WHAT RAMIPRIL IS USED
FOR
The name of your medicine is APO-
Ramipril. It contains the active
ingredient, ramipril.
Ramipril belongs to a group of
medicines called angiotensin
converting enzyme (ACE) inhibitors.
Ramipril is used to treat:
•
high blood pressure
(hypertension)
•
some heart conditions, such as
heart failure after a heart attack
•
kidney problems in some patients.
Ramipril is also used to reduce the
risk of cardiovascular problems and
complications in patients aged 55
years or more with heart or blood
vessel disease, or diabetes.
HIGH BLOOD PRESSURE
(HYPERTENSION)
Ramipril is used to lower high blood
pressure (hypertension). Everyone
has blood pressure. This pressure
helps get your blood all around your
body. Your blood pressure may be
different at different times of the day
and can be influenced by how busy
or worried you are. You have high
blood pressure when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
high blood pressure. The only way of
knowing that you have hi

Summary of Product characteristics

Product Information – Australia 
APO-Ramipril Capsules 
Page 1 
APO-RAMIPRIL CAPSULES 

NAME OF THE MEDICINE 
Non-proprietary name:  Ramipril 

Chemical Name: 
(2_S_,3a_S_,6a_S_)-1-[(2_S_)-2-[[(1_S_)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino] 
propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid 

Structural Formula: 

Ramipril has 5 chiral centres, with S-configuration in
all 5 asymmetric carbon atoms. 

Molecular Formula: 
C
23
H
32
N
2
O
5

Molecular Weight: 
416.51 

CAS Registry Number: 
87333-19-5 

DESCRIPTION 
Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid
derivative. It is a white, crystalline 
substance  sparingly soluble in water and soluble
in polar organic solvents and buffered aqueous 
solutions. Ramipril melts between 105°C and 112°C.   

PHARMACOLOGY 
MECHANISM OF ACTION 
Ramipril is a pro-drug which, after absorption from the gastrointestinal tract, is hydrolysed in the liver 
to form the active moiety, ramiprilat.  Ramipril and
ramiprilat inhibit angiotensin-converting enzyme 
(ACE) which is identical to kininase  II.  This converting
enzyme (ACE)  is a peptidyl dipeptidase that 
catalyses the conversion of angiotensin I to
the vasoconstrictor substance, angiotensin II. Angiotensin 
II also stimulates aldosterone secretion
by the adrenal cortex, thus inhibition of ACE results in 
decreased plasma
angiotensin II, which leads to decreased vasopressor activity and to decreased 
aldosterone secretion. The latter decrease may result in a
small increase in serum potassium. 

Kininase  II is one of the enzymes responsible for the
degradation of bradykinin, a potent 
vasodepressor peptide.  The
inhibition of kininase  II activity by ramipril  prevents the
degradation of 
bradykinin
thus leading to increased levels of this potent vasodepressor substance.  While