Land: Malaysia
Språk: engelska
Källa: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Aspirin
UNIMED SDN BHD
Aspirin
30tablet Tablets
KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.
_ Consumer Medication Information Leaflet (RiMUP)_ MILLISPIRIN ACETYL SALICYLIC ACID SOLUBLE TABLET 300 MG (Aspirin) Aspirin (300mg) WHAT IS IN THE LEAFLET? 1. What MILLISPIRIN is used for 2. How MILLISPIRIN works 3. Before you use MILLISPIRIN 4. How to use MILLISPIRIN 5. While you are using it 6. Side effects 7. Store and Disposal of MILLISPIRIN 8. Product Description 9. Manufacturer 10. Product Registration Holder 11. Date of Revision 1. WHAT MILLISPIRIN IS USED FOR MILLISPIRIN can be used for: Relief of mild to moderate pain such as joint pain, period pain, muscle pain, nerve pain and headache Reduce or relief of inflammation Relief of fever Under advice by a doctor, MILLISPIRIN can also be used to prevent blood clots especially after a heart attack or in patients with unstable angina (chest pain) or reduced blood flow in the brain. 2. HOW MILLISPIRIN WORKS Aspirin belongs to a group of medicines known as non-steroidal anti- inflammatory drugs (NSAIDS) which have analgesic (pain relieving), anti- inflammatory (inflammation reducing) and antipyretic (temperature reducing) properties. Aspirin can also be used to reduce the chances of blood clots and help to prevent blocking of blood vessel which can lead to events such as stroke, heart attack or death. 3. BEFORE YOU USE MILLISPIRIN WHEN YOU MUST NOT USE IT Do not use MILLISPIRIN if you: Are allergic (hypersensitive) to aspirin, salicylates or NSAIDs or other ingredients in the product Are prone to indigestion or known to have a stomach or small intestine ulcer Have severe kidney, heart or liver problem Are receiving anticoagulant (medicine used to prevent blood clot) Are a patient with haemophilia or other bleeding disorders Are a patient with gout PREGNANCY AND BREAST-FEEDING Do not use MILLISPIRIN if you are pregnant or trying for a baby unless directed by your doctor. MILLISPIRIN can prolong labour and affect blood clotting in the mother or baby. If you are breastfeeding, you should not take MILLISPIRIN because it passes in Läs hela dokumentet
MILLISPIRIN Acetyl Salicylic Acid Soluble Tablets 300 mg (Aspirin) DESCRIPTION White, circular, biconvex, uncoated tablets with break line. PHARMACODYNAMICS At higher doses, aspirin is an effective anti-inflammatory agent, partially due to inhibition of inflammatory mediators via cyclo-oxygenase inhibition in peripheral tissues. Acetyl salicylic acid affects platelet aggregation by irreversibly inhibiting prostaglandin cyclo-oxygenase. This effect lasts for the life of the platelet and prevents the formation of the platelet aggregating factor thromboxane A 2 . Non-acetylated salicylates do not inhibit this enzyme and have no effect on platelet aggregation. At somewhat higher doses, aspirin reversibly inhibits the formation of prostaglandin I 2 (prostacyclin), which is an arterial vasodilator and inhibits platelet aggregation. PHARMACOKINETICS ABSORPTION: Aspirin after oral administration is generally well absorbed from the gastrointestinal (GI) tract. Following absorption, aspirin is hydrolyzed to salicylic acid with peak plasma levels of salicylic acid occurring within 1-2 hours of dosing. The rate of absorption from the GI tract is dependent upon the dosage form, the presence or absence of food, gastric pH and other physiologic factors. DISTRIBUTION: Salicylic acid is widely distributed to all tissues and fluids in the body including the central nervous system (CNS), breast milk and fetal tissues. The highest concentrations are found in the plasma, liver, renal cortex, heart and lungs. The protein binding of salicylate is concentration-dependent, i.e., non-linear. At low concentrations (< 100 micrograms/milliliter (mcg/ml)), approximately 90 percent of plasma salicylate is bound to albumin while at higher concentrations (> 400 mcg/rnl.), only about 75 percent is bound. The early signs of salicylic overdose (salicylism), including tinnitus (ringing in the ears), occur at plasma concentrations approximating 200 mcg/ml. METABOLISM: Aspirin is rapidly hydrolyzed in the plasma to salicylic acid such that plasma leve Läs hela dokumentet