MILLISPIRIN Acetyl Salicylic Acid Soluble Tablets 300 mg (Aspirin)

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Aspirin

Boleh didapati daripada:

UNIMED SDN BHD

INN (Nama Antarabangsa):

Aspirin

Unit dalam pakej:

30tablet Tablets

Dikeluarkan oleh:

KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.

Risalah maklumat

_ Consumer Medication Information Leaflet (RiMUP)_
MILLISPIRIN
ACETYL SALICYLIC ACID SOLUBLE TABLET 300 MG
(Aspirin)
Aspirin (300mg)
WHAT IS IN THE LEAFLET?
1.
What MILLISPIRIN is used for
2.
How MILLISPIRIN works
3.
Before you use MILLISPIRIN
4.
How to use MILLISPIRIN
5.
While you are using it
6.
Side effects
7.
Store
and
Disposal
of
MILLISPIRIN
8.
Product Description
9.
Manufacturer
10.
Product Registration Holder
11.
Date of Revision
1.
WHAT MILLISPIRIN IS USED
FOR
MILLISPIRIN can be used for:

Relief of mild to moderate pain such
as joint pain, period pain, muscle
pain, nerve pain and headache

Reduce or relief of inflammation

Relief of fever
Under
advice
by
a
doctor,
MILLISPIRIN
can
also
be
used
to
prevent blood clots especially after a
heart attack or in patients with unstable
angina (chest pain) or reduced blood
flow in the brain.
2.
HOW MILLISPIRIN
WORKS
Aspirin
belongs
to
a
group
of
medicines known as non-steroidal anti-
inflammatory drugs (NSAIDS) which
have analgesic (pain relieving), anti-
inflammatory (inflammation reducing)
and antipyretic (temperature reducing)
properties.
Aspirin can also be used to reduce the
chances
of
blood
clots
and
help
to
prevent blocking of blood vessel which
can lead to events such as stroke, heart
attack or death.
3.
BEFORE YOU USE
MILLISPIRIN
WHEN YOU MUST NOT USE IT
Do not use MILLISPIRIN if you:

Are
allergic
(hypersensitive)
to
aspirin,
salicylates
or
NSAIDs
or
other ingredients in the product

Are prone to indigestion or known to
have a stomach or small intestine
ulcer

Have severe kidney, heart or liver
problem

Are
receiving
anticoagulant
(medicine used to prevent blood clot)

Are a patient with haemophilia or
other bleeding disorders

Are a patient with gout
PREGNANCY AND BREAST-FEEDING
Do not use MILLISPIRIN if you are
pregnant or trying for a baby unless
directed by your doctor. MILLISPIRIN
can prolong labour and affect blood
clotting in the mother or baby.
If you are breastfeeding, you should not
take MILLISPIRIN because it passes
in

Ciri produk

MILLISPIRIN
Acetyl Salicylic Acid Soluble Tablets 300 mg (Aspirin)
DESCRIPTION
White, circular, biconvex, uncoated tablets with break line.
PHARMACODYNAMICS
At higher doses, aspirin is an effective anti-inflammatory agent,
partially due to inhibition of inflammatory mediators via
cyclo-oxygenase inhibition in peripheral
tissues. Acetyl salicylic acid affects platelet aggregation by
irreversibly inhibiting prostaglandin cyclo-oxygenase. This effect
lasts for the life of the platelet and
prevents the formation of the platelet aggregating factor thromboxane
A
2
. Non-acetylated salicylates do not inhibit this enzyme and have no
effect on platelet
aggregation. At somewhat higher doses, aspirin reversibly inhibits the
formation of prostaglandin I
2
(prostacyclin), which is an arterial vasodilator and inhibits platelet
aggregation.
PHARMACOKINETICS
ABSORPTION:
Aspirin after oral administration is generally well absorbed from the
gastrointestinal (GI) tract. Following absorption, aspirin is
hydrolyzed to salicylic
acid with peak plasma levels of salicylic acid occurring within 1-2
hours of dosing. The rate of absorption from the GI tract is dependent
upon the dosage form, the
presence or absence of food, gastric pH and other physiologic factors.
DISTRIBUTION:
Salicylic acid is widely distributed to all tissues and fluids in the
body including the central nervous system (CNS), breast milk and fetal
tissues. The
highest concentrations are found in the plasma, liver, renal cortex,
heart and lungs. The protein binding of salicylate is
concentration-dependent, i.e., non-linear. At
low concentrations (< 100 micrograms/milliliter (mcg/ml)),
approximately 90 percent of plasma salicylate is bound to albumin
while at higher concentrations (> 400
mcg/rnl.), only about 75 percent is bound. The early signs of
salicylic overdose (salicylism), including tinnitus (ringing in the
ears), occur at plasma concentrations
approximating 200 mcg/ml.
METABOLISM:
Aspirin is rapidly hydrolyzed in the plasma to salicylic acid such
that plasma leve