Land: USA
Språk: engelska
Källa: NLM (National Library of Medicine)
GENTAMICIN SULFATE (UNII: 8X7386QRLV) (GENTAMICIN - UNII:T6Z9V48IKG), BETAMETHASONE VALERATE (UNII: 9IFA5XM7R2) (BETAMETHASONE - UNII:9842X06Q6M)
Butler Animal health Supply, LLC dba Covetrus North America
TOPICAL
PRESCRIPTION
Topical spray VETERINARY FOR TOPICAL USE IN DOGS ONLY For the treatment of infected superficial lesions in dogs caused by bacteria susceptible to gentamicin. Read accompanying directions carefully. Keep Out of Reach of Children. If hypersensitivity to any of the components occurs, discontinue treatment and institute appropriate therapy.
Plastic spray bottles containing 60 mL, 120 mL, and 240 mL of Gentamicin sulfate, USP with betamethasone valerate, USP topical spray
Abbreviated New Animal Drug Application
GENTAMICIN SULFATE WITH BETAMETHASONE VALERATE- GENTAMICIN SULFATE SPRAY BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA ---------- GENTAMICIN SULFATE, USP WITH BETAMETHASONE VALERATE, USP TOPICAL SPRAY VETERINARY FOR TOPICAL USE IN DOGS ONLY CAUTION:FEDERAL LAW RESTRICTS THIS DRUG TO USE BY OR ON THE ORDER OF A LICENSED VETERINARIAN. FOR ANIMAL USE ONLY KEEP OUT OF REACH OF CHILDREN DESCRIPTION: Each mL contains: gentamicin sulfate, USP equivalent to 0.57 mg gentamicin base, betamethasone valerate, USP equivalent to 0.284 mg betamethasone, 163 mg isopropyl alcohol, propylene glycol, methylparaben and propylparaben as preservatives, purified water q.s. Hydrochloric acid may be added to adjust pH. CHEMISTRY: Gentamicin is a mixture of aminoglycoside antibiotics derived from the fermentation of _Micromonospora purpurea_. Gentamicin sulfate veterinary is a mixture of sulfate salts of the antibiotics produced in this fermentation. The salts are weakly acidic and freely soluble in water. Gentamicin sulfate veterinary contains not less than 500 micrograms of gentamicin base per milligram. Betamethasone valerate is a synthetic glucocorticoid. PHARMACOLOGY: Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. _In vitro_, gentamicin is bactericidal against a wide variety of gram-positive and gram-negative bacteria isolated from domestic animals. Specifically, gentamicin is active against the following organisms isolated from canine skin:_ Alcaligenes_ sp., _Citrobacter_ sp., _Klebsiella_ sp., _Pseudomonas aeruginosa_, indole- positive and -negative _Proteus_ sp., _Escherichia coli_, _Enterobacter_ sp., _Staphylococcus_ sp., and _Streptococcus_ sp. Betamethasone valerate emerged from intensive research as the most promising of some 50 newly synthesized corticosteroids in the experimental model described by McKenzie, et al. This human bioassay technique has been found reliable for evaluating 1,2 3 the vasoconstrictor properties of new topical cort Läs hela dokumentet