Gentamicin sulfate, USP with betamethasone valerate, USP

מדינה: ארצות הברית

שפה: אנגלית

מקור: NLM (National Library of Medicine)

מרכיב פעיל:

GENTAMICIN SULFATE (UNII: 8X7386QRLV) (GENTAMICIN - UNII:T6Z9V48IKG), BETAMETHASONE VALERATE (UNII: 9IFA5XM7R2) (BETAMETHASONE - UNII:9842X06Q6M)

זמין מ:

Butler Animal health Supply, LLC dba Covetrus North America

מסלול נתינה (של תרופות):

TOPICAL

סוג מרשם:

PRESCRIPTION

סממני תרפויטית:

Topical spray VETERINARY FOR TOPICAL USE IN DOGS ONLY For the treatment of infected superficial lesions in dogs caused by bacteria susceptible to gentamicin. Read  accompanying directions carefully. Keep Out of Reach of Children. If hypersensitivity to any of the components occurs, discontinue treatment and institute appropriate therapy.

leaflet_short:

Plastic spray bottles containing 60 mL, 120 mL, and 240 mL of Gentamicin sulfate, USP with betamethasone valerate, USP topical spray

מצב אישור:

Abbreviated New Animal Drug Application

מאפייני מוצר

GENTAMICIN SULFATE WITH BETAMETHASONE VALERATE- GENTAMICIN
SULFATE SPRAY
BUTLER ANIMAL HEALTH SUPPLY, LLC DBA COVETRUS NORTH AMERICA
----------
GENTAMICIN
SULFATE, USP WITH
BETAMETHASONE VALERATE, USP
TOPICAL SPRAY
VETERINARY
FOR TOPICAL USE IN DOGS ONLY
CAUTION:FEDERAL LAW RESTRICTS THIS DRUG TO USE BY OR ON THE ORDER OF A
LICENSED VETERINARIAN.
FOR ANIMAL USE ONLY
KEEP OUT OF REACH OF CHILDREN
DESCRIPTION:
Each mL contains: gentamicin sulfate, USP equivalent to 0.57 mg
gentamicin base,
betamethasone valerate, USP equivalent to 0.284 mg betamethasone, 163
mg isopropyl
alcohol, propylene glycol, methylparaben and propylparaben as
preservatives, purified
water q.s. Hydrochloric acid may be added to adjust pH.
CHEMISTRY:
Gentamicin is a mixture of aminoglycoside antibiotics derived from the
fermentation of
_Micromonospora purpurea_. Gentamicin sulfate veterinary is a mixture
of sulfate salts of
the antibiotics produced in this fermentation. The salts are weakly
acidic and freely
soluble in water.
Gentamicin sulfate veterinary contains not less than 500 micrograms of
gentamicin base
per milligram.
Betamethasone valerate is a synthetic glucocorticoid.
PHARMACOLOGY:
Gentamicin, a broad-spectrum antibiotic, is a highly effective topical
treatment for
bacterial infections of the skin. _In vitro_, gentamicin is
bactericidal against a wide variety
of gram-positive and gram-negative bacteria isolated from domestic
animals.
Specifically, gentamicin is active against the following organisms
isolated from canine
skin:_ Alcaligenes_ sp., _Citrobacter_ sp., _Klebsiella_ sp.,
_Pseudomonas aeruginosa_, indole-
positive and -negative _Proteus_ sp., _Escherichia coli_,
_Enterobacter_ sp., _Staphylococcus_
sp., and _Streptococcus_ sp.
Betamethasone valerate emerged from intensive research as the most
promising of
some 50 newly synthesized corticosteroids in the experimental model
described by
McKenzie,
et al. This human bioassay technique has been found reliable for
evaluating
1,2
3
the vasoconstrictor properties of new topical cort