Krajina: Spojené štáty
Jazyk: angličtina
Zdroj: NLM (National Library of Medicine)
VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)
St Marys Medical Park Pharmacy
VERAPAMIL HYDROCHLORIDE
VERAPAMIL HYDROCHLORIDE 120 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
VERAPAMIL - VERAPAMIL HYDROCHLORIDE TABLET, FILM COATED, EXTENDED RELEASE ST MARYS MEDICAL PARK PHARMACY ---------- VERAPAMIL HYDROCHLORIDE EXTENDED-RELEASE TABLETS USP DESCRIPTION Verapamil hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). Verapamil Hydrochloride Extended-Release Tablets, USP is available for oral administration as light green, capsule shaped, scored, biconvex film-coated tablets containing 240 mg verapamil hydrochloride; pink, oval shaped, scored, biconvex film-coated tablets containing 180 mg verapamil hydrochloride; and light pink, oval shaped, biconvex film-coated tablets, containing 120 mg verapamil hydrochloride. The tablets are designed for sustained-release of the drug in the gastrointestinal tract, sustained-release characteristics are not altered when the tablet is divided in half. The structural formula of verapamil HCl is given below: C H N O •HCl............. M.W. 491.06 Benzeneacetonitrile, α [3-[[2-(3,4-dimethoxyphenyl) ethyl] methylamino]propyl]-3,4 dimethoxy-α-(1- methylethyl) hydrochloride Verapamil HCl is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil HCl is not chemically related to other cardioactive drugs. In addition to verapamil HCl, the verapamil hydrochloride extended-release tablet contains the following ingredients: sodium alginate, hypromellose, hydroxypropyl cellulose, magnesium stearate, colloidal silicon dioxide, polyethylene glycol, and titanium dioxide. The following are the color additives per tablet strength: Strength (mg) Color Additive(s) 120 Ferric Oxide Red and Black Iron Oxide 180 Ferric Oxide Orange 240 Indigotine Aluminium Lake 12-14% and D&C Yellow #10 Aluminium Lake USP Dissolution Test pending. CLINICAL PHARMACOLOGY Verapamil HCl is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell Prečítajte si celý dokument