VERAPAMIL hydrochloride tablet film coated extended release

Kraj: Stany Zjednoczone

Język: angielski

Źródło: NLM (National Library of Medicine)

Składnik aktywny:

VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)

Dostępny od:

St Marys Medical Park Pharmacy

INN (International Nazwa):

VERAPAMIL HYDROCHLORIDE

Skład:

VERAPAMIL HYDROCHLORIDE 120 mg

Typ recepty:

PRESCRIPTION DRUG

Status autoryzacji:

Abbreviated New Drug Application

Charakterystyka produktu

VERAPAMIL - VERAPAMIL HYDROCHLORIDE TABLET, FILM COATED, EXTENDED
RELEASE
ST MARYS MEDICAL PARK PHARMACY
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VERAPAMIL HYDROCHLORIDE EXTENDED-RELEASE TABLETS USP
DESCRIPTION
Verapamil hydrochloride is a calcium ion influx inhibitor (slow
channel blocker or calcium ion
antagonist). Verapamil Hydrochloride Extended-Release Tablets, USP is
available for oral
administration as light green, capsule shaped, scored, biconvex
film-coated tablets containing 240 mg
verapamil hydrochloride; pink, oval shaped, scored, biconvex
film-coated tablets containing 180 mg
verapamil hydrochloride; and light pink, oval shaped, biconvex
film-coated tablets, containing 120 mg
verapamil hydrochloride. The tablets are designed for
sustained-release of the drug in the
gastrointestinal tract, sustained-release characteristics are not
altered when the tablet is divided in half.
The structural formula of verapamil HCl is given below:
C
H N O •HCl............. M.W. 491.06
Benzeneacetonitrile, α [3-[[2-(3,4-dimethoxyphenyl) ethyl]
methylamino]propyl]-3,4 dimethoxy-α-(1-
methylethyl) hydrochloride
Verapamil HCl is an almost white, crystalline powder, practically free
of odor, with a bitter taste. It is
soluble in water, chloroform and methanol. Verapamil HCl is not
chemically related to other
cardioactive drugs.
In addition to verapamil HCl, the verapamil hydrochloride
extended-release tablet contains the
following ingredients: sodium alginate, hypromellose, hydroxypropyl
cellulose, magnesium stearate,
colloidal silicon dioxide, polyethylene glycol, and titanium dioxide.
The following are the color
additives per tablet strength:
Strength (mg) Color Additive(s)
120 Ferric Oxide Red and Black Iron Oxide
180 Ferric Oxide Orange
240 Indigotine Aluminium Lake 12-14% and D&C Yellow #10 Aluminium Lake
USP Dissolution Test pending.
CLINICAL PHARMACOLOGY
Verapamil HCl is a calcium ion influx inhibitor (slow channel blocker
or calcium ion antagonist) that
exerts its pharmacologic effects by modulating the influx of ionic
calcium across the cell