Land: Vereinigte Staaten
Sprache: Englisch
Quelle: NLM (National Library of Medicine)
VERAPAMIL HYDROCHLORIDE (UNII: V3888OEY5R) (VERAPAMIL - UNII:CJ0O37KU29)
St Marys Medical Park Pharmacy
VERAPAMIL HYDROCHLORIDE
VERAPAMIL HYDROCHLORIDE 120 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
VERAPAMIL - VERAPAMIL HYDROCHLORIDE TABLET, FILM COATED, EXTENDED RELEASE ST MARYS MEDICAL PARK PHARMACY ---------- VERAPAMIL HYDROCHLORIDE EXTENDED-RELEASE TABLETS USP DESCRIPTION Verapamil hydrochloride is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist). Verapamil Hydrochloride Extended-Release Tablets, USP is available for oral administration as light green, capsule shaped, scored, biconvex film-coated tablets containing 240 mg verapamil hydrochloride; pink, oval shaped, scored, biconvex film-coated tablets containing 180 mg verapamil hydrochloride; and light pink, oval shaped, biconvex film-coated tablets, containing 120 mg verapamil hydrochloride. The tablets are designed for sustained-release of the drug in the gastrointestinal tract, sustained-release characteristics are not altered when the tablet is divided in half. The structural formula of verapamil HCl is given below: C H N O •HCl............. M.W. 491.06 Benzeneacetonitrile, α [3-[[2-(3,4-dimethoxyphenyl) ethyl] methylamino]propyl]-3,4 dimethoxy-α-(1- methylethyl) hydrochloride Verapamil HCl is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform and methanol. Verapamil HCl is not chemically related to other cardioactive drugs. In addition to verapamil HCl, the verapamil hydrochloride extended-release tablet contains the following ingredients: sodium alginate, hypromellose, hydroxypropyl cellulose, magnesium stearate, colloidal silicon dioxide, polyethylene glycol, and titanium dioxide. The following are the color additives per tablet strength: Strength (mg) Color Additive(s) 120 Ferric Oxide Red and Black Iron Oxide 180 Ferric Oxide Orange 240 Indigotine Aluminium Lake 12-14% and D&C Yellow #10 Aluminium Lake USP Dissolution Test pending. CLINICAL PHARMACOLOGY Verapamil HCl is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell Lesen Sie das vollständige Dokument