Krajina: Kanada
Jazyk: angličtina
Zdroj: Health Canada
NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE)
BAXTER CORPORATION
C01CA03
NOREPINEPHRINE
0.032MG
SOLUTION
NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE) 0.032MG
INTRAVENOUS
15G/50G
Ethical
ALPHA-AND BETA-ADRENERGIC AGONISTS
Active ingredient group (AIG) number: 0131301003; AHFS:
APPROVED
2020-07-02
_Prescribing Information - Norepinephrine Bitartrate in 5% Dextrose Injection _ _USP)_ _Page 1 of 13 _ PRESCRIBING INFORMATION NOREPINEPHRINE BITARTRATE IN 5% DEXTROSE INJECTION 0.016 mg / mL and 0.032 mg / mL norepinephrine (as norepinephrine bitartrate) Sterile Solution for Intravenous Infusion Manufacturer Standard SYMPATHOMIMETIC AMINE FOR USE IN HYPOTENSIVE EMERGENCIES Baxter Corporation Date of Revision: June 24, 2021 Mississauga, Ontario L5N 0C2 Control No.: 249005 Baxter and VIAFLO are Trademarks of Baxter International Inc. _Prescribing Information - Norepinephrine Bitartrate in 5% Dextrose Injection _ _USP)_ _Page 2 of 13 _ DESCRIPTION Norepinephrine (sometimes referred to as _ l-arterenol/Levarterenol or l-norepinephrine) _is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom. ACTIONS Norepinephrine bitartrate functions as a powerful peripheral vasoconstrictor (alpha-adrenergic action) and as a potent inotropic stimulator of the heart and dilator of coronary arteries (beta- adrenergic action). Both of these actions result in an increase in systemic blood pressure and coronary artery blood flow. Cardiac output will vary reflexly in response to systemic hypertension but is usually increased in hypotensive man when the blood pressure is raised to an optimal level. In myocardial infarction accompanied by hypotension. Norepinephrine bitartrate usually increases aortic blood pressure, coronary artery blood flow, and myocardial oxygenation, thereby helping to limit the area of myocardial ischemia and infarction. Venous return is increased and the heart tends to resume a more normal rate and rhythm than in the hypotensive state. In hypotension that persists after correction of blood volume deficits, norepinephrine bitartrate helps raise the blood pressure to an optimal level and establish a more adequate circulation. In _myocardial infarction, _norepinephrine bitartrate has been shown to increase greatly the patient survival rate. Norepinephrine bitartr Prečítajte si celý dokument