国: マレーシア
言語: 英語
ソース: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
OXYTETRACYCLINE DIHYDRATE
Taseen Trading Sdn Bhd
OXYTETRACYCLINE DIHYDRATE
100.00 mcg/mL
Industrial Veterinaria, S.A. (INVESA)
PACKAGE INSERT BRAND OR PRODUCT NAME OXITETRACICLINA 200mg/ml L.A. Solution for Injection Oxytetracycline NAME AND STRENGTH OF ACTIVE SUBSTANCE(S) Oxytetracycline Dihydrate 215.6mg/ml PRODUCT DESCRIPTION A transparent, yellow, slightly dense and viscous solution. PHARMACODYNAMICS Oxytetracycline is a bacteriostatic antibiotic that inhibits protein synthesis in susceptible bacteria. Inside the cell it binds irreversibly to receptors on the 30S subunit of the bacterial ribosome where it interferes with the binding of the aminoacyl-transfer RNA to the acceptor site on the messenger RNA ribosome complex. This effectively prevents the addition of amino acids to the elongating peptide chain, inhibiting protein synthesis. The product is specifically formulated to provide a prolonged action resulting in sustained antibacterial activity. Oxytetracycline had been shown to be effective in vitro against the following bacterial species: Bordetella bronchiseptica, Corynebacterium pyogenes, Erysipelothrix rhusiopathiae, Escherichia coli, Haemophilus somnus, Pasteurella haemolytica, Pasteurella multocida, Salmonella dublin, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus faecalis, Streptococcus pyogenes and Streptococcus uberis. PHARMACOKINETICS Blood levels persist for at least 4 days after administration by the intramuscular route. Maximum blood levels are achieved between 4 and 8 hours following intramuscular administration. ENVIRONMENTAL PROPERTIES not relevant INDICATION The product is indicated for use in cattle, sheep and pigs in the treatment of: - Atrophic rhinitis caused by Bordetella bronchiseptica, Mannheimia haemolytica and Pasteurella multocida. - Navel/joint ill caused by Arcanobacterium pyogenes, E. coli or Staphylococcus aureus. - Mastits caused by Corynebacterium pyogenes, E. coli, Staphylococcus aureus, Streptococcus agalactiae or Streptococcus uberis. - Metritis caused by E. coli or Streptococcus pyogenes. - Pasteurellosis and infections of the respiratory tract caused by Mannheimia haemolytica 完全なドキュメントを読む