国: シンガポール
言語: 英語
ソース: HSA (Health Sciences Authority)
Ibuprofen acid 400 mg eqv Ibuprofen Lysine
RECKITT BENCKISER (SINGAPORE) PTE LTD
M01AE01
684MG
TABLET, FILM COATED
Ibuprofen acid 400 mg eqv Ibuprofen Lysine 684MG
ORAL
Prescription Only
Reckitt Benckiser Healthcare International Limited
ACTIVE
2013-06-14
NUROFEN EXPRESS 684MG CAPLET IBUPROFEN LYSINE 684MG Date of text revision: May 2013 PRODUCT DESCRIPTION Film-coated, white, capsule-shaped tablet, printed with an indentifying logo in black on one face. Also contains: Povidone, sodium starch glycollate Type A, magnesium stearate, hypromellose, talc, Opaspray White M- 1-7111B (contains hypromellose and titanium dioxide (E171)) and Black Printing Ink (contains shellac, Iron oxide black (E172) and propylene glycol). PHARMACODYNAMICS Ibuprofen lysine is the lysine salt of ibuprofen, a propionic acid derivative, having analgesic, anti-inflammatory and antipyretic activity. The therapeutic effects of ibuprofen lysine as a non steroidal anti-inflammatory drug are thought to result from inhibitory activity on prostaglandin synthesis. Following oral administration, ibuprofen lysine dissociates to ibuprofen acid and lysine. Lysine has no recognized pharmacological activity. The pharmacological properties of ibuprofen lysine, therefore, are the same as those of ibuprofen acid. Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are dosed concomitantly. In one study, when a single dose of ibuprofen 400mg was taken within 8 hours before or within 30 minutes after immediate release aspirin dosing (81mg), a decreased effect of ASA on the formation of thromboxane or platelet aggregation occurred. However, the limitations of these data and the uncertainties regarding extrapolation of ex vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no relevant effect is conside 完全なドキュメントを読む
NUROFEN EXPRESS 684MG CAPLET IBUPROFEN LYSINE 684MG PRODUCT DESCRIPTION Film-coated, white, capsule-shaped tablet, printed with an indentifying logo in black on one face. Also contains: Povidone, sodium starch glycollate Type A, magnesium stearate, hypromellose, talc, Opaspray White M-1-7111B (contains hypromellose and titanium dioxide (E171)) and Black Printing Ink (contains shellac, Iron oxide black (E172) and propylene glycol). PHARMACODYNAMICS Ibuprofen lysine is the lysine salt of ibuprofen, a propionic acid derivative, having analgesic, anti-inflammatory and antipyretic activity. The therapeutic effects of ibuprofen lysine as a non steroidal anti-inflammatory drug are thought to result from inhibitory activity on prostaglandin synthesis. Following oral administration, ibuprofen lysine dissociates to ibuprofen acid and lysine. Lysine has no recognized pharmacological activity. The pharmacological properties of ibuprofen lysine, therefore, are the same as those of ibuprofen acid. Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are dosed concomitantly. In one study, when a single dose of ibuprofen 400mg was taken within 8 hours before or within 30 minutes after immediate release aspirin dosing (81mg), a decreased effect of ASA on the formation of thromboxane or platelet aggregation occurred. However, the limitations of these data and the uncertainties regarding extrapolation of ex vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no relevant effect is considered to be likely for occasional ibuprofen use. PHARMACOKINETICS Most pharmacokinetic data obtained following the administration of ibuprofen acid also apply to ibuprofen lysine. Peak plasma concentrations occur 1-2 hours after administration of ibuprofen acid. However, ibuprofen is more rapidly absorbed from the gastrointestinal tract following the administration of Nurofen Express 684mg Caplet, with peak plasma concentrations o 完全なドキュメントを読む