NUROFEN EXPRESS CAPLETS 684MG

Country: Сингапур

Језик: Енглески

Извор: HSA (Health Sciences Authority)

Активни састојак:

Ibuprofen acid 400 mg eqv Ibuprofen Lysine

Доступно од:

RECKITT BENCKISER (SINGAPORE) PTE LTD

АТЦ код:

M01AE01

Дозирање:

684MG

Фармацеутски облик:

TABLET, FILM COATED

Састав:

Ibuprofen acid 400 mg eqv Ibuprofen Lysine 684MG

Пут администрације:

ORAL

Тип рецептора:

Prescription Only

Произведен од:

Reckitt Benckiser Healthcare International Limited

Статус ауторизације:

ACTIVE

Датум одобрења:

2013-06-14

Информативни летак

NUROFEN EXPRESS 684MG CAPLET 
IBUPROFEN LYSINE 684MG 

Date of text revision: May 2013 
PRODUCT DESCRIPTION 
Film-coated, white, capsule-shaped tablet, printed with an indentifying logo in black on one face.  
Also contains: Povidone, sodium starch glycollate Type A, magnesium stearate, hypromellose, talc, Opaspray White M-
1-7111B (contains hypromellose and titanium dioxide (E171)) and Black Printing Ink (contains shellac, Iron oxide black 
(E172) and propylene glycol). 

PHARMACODYNAMICS 
Ibuprofen  lysine  is  the  lysine  salt  of  ibuprofen,  a  propionic  acid  derivative,  having  analgesic,  anti-inflammatory  and 
antipyretic activity.  The therapeutic effects of ibuprofen lysine as a non steroidal anti-inflammatory drug are thought to 
result from inhibitory activity on prostaglandin synthesis. 
Following  oral  administration,  ibuprofen  lysine  dissociates  to  ibuprofen  acid  and  lysine.    Lysine  has  no  recognized 
pharmacological  activity.    The  pharmacological  properties  of  ibuprofen  lysine,  therefore,  are  the  same  as  those  of 
ibuprofen acid. 
Experimental data suggest that ibuprofen may inhibit the effect of low dose aspirin on platelet aggregation when they are 
dosed concomitantly.  In one study, when a single dose of ibuprofen 400mg was taken within 8  hours before or within 30 
minutes  after  immediate  release  aspirin  dosing  (81mg),  a  decreased  effect  of  ASA  on  the  formation  of  thromboxane  or 
platelet aggregation occurred.  However, the limitations of these  data and the uncertainties regarding extrapolation of ex 
vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no relevant 
effect is conside

Карактеристике производа

NUROFEN EXPRESS 684MG CAPLET
IBUPROFEN LYSINE 684MG
PRODUCT DESCRIPTION
Film-coated, white, capsule-shaped tablet, printed with an
indentifying logo in black on one face. Also contains: Povidone,
sodium
starch glycollate Type A, magnesium stearate, hypromellose, talc,
Opaspray White M-1-7111B (contains hypromellose and titanium
dioxide (E171)) and Black Printing Ink (contains shellac, Iron oxide
black (E172) and propylene glycol).
PHARMACODYNAMICS
Ibuprofen lysine is the lysine salt of ibuprofen, a propionic acid
derivative, having analgesic, anti-inflammatory and antipyretic
activity. The therapeutic effects of ibuprofen lysine as a non
steroidal anti-inflammatory drug are thought to result from
inhibitory activity on prostaglandin synthesis.
Following oral administration, ibuprofen lysine dissociates to
ibuprofen acid and lysine. Lysine has no recognized
pharmacological activity. The pharmacological properties of ibuprofen
lysine, therefore, are the same as those of ibuprofen acid.
Experimental data suggest that ibuprofen may inhibit the effect of low
dose aspirin on platelet aggregation when they are dosed
concomitantly. In one study, when a single dose of ibuprofen 400mg was
taken within 8 hours before or within 30 minutes after
immediate release aspirin dosing (81mg), a decreased effect of ASA on
the formation of thromboxane or platelet aggregation
occurred. However, the limitations of these data and the uncertainties
regarding extrapolation of ex vivo data to the clinical
situation imply that no firm conclusions can be made for regular
ibuprofen use, and no relevant effect is considered to be likely
for occasional ibuprofen use.
PHARMACOKINETICS
Most pharmacokinetic data obtained following the administration of
ibuprofen acid also apply to ibuprofen lysine. Peak plasma
concentrations
occur 1-2 hours after administration of ibuprofen acid. However,
ibuprofen is more rapidly absorbed from the gastrointestinal tract
following the
administration of Nurofen Express 684mg Caplet, with peak plasma
concentrations o