NOREPINEPHRINE BITARTRATE INJECTION USP SOLUTION

国: カナダ

言語: 英語

ソース: Health Canada

有効成分:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE)

から入手可能:

GENERIC MEDICAL PARTNERS INC

ATCコード:

C01CA03

INN（国際名）:

NOREPINEPHRINE

投薬量:

1MG

医薬品形態:

SOLUTION

構図:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE) 1MG

投与経路:

INTRAVENOUS

パッケージ内のユニット:

15G/50G

処方タイプ:

Ethical

治療領域:

ALPHA-AND BETA-ADRENERGIC AGONISTS

製品概要:

Active ingredient group (AIG) number: 0131301001; AHFS:

認証ステータス:

APPROVED

承認日:

2019-02-08

製品の特徴

PRESCRIBING INFORMATION
NOREPINEPHRINE BITARTRATE INJECTION USP
(norepinephrine bitartrate injection USP)
Solution, 1 mg norepinephrine/mL
SYMPATHOMIMETIC AMINE FOR USE IN HYPOTENSIVE EMERGENCIES
Generic Medical Partners Inc.
1500 Don Mills Road, Suite 406
Toronto, ON
M3B 3K4
Date of Revision:
August 18, 2020
Control No. : 241220
2
DESCRIPTION
Norepinephrine (sometimes referred to as _ l-arterenol/Levarterenol or
l-norepinephrine)_ is a
sympathomimetic amine which differs from epinephrine by the absence of
a methyl group on the
nitrogen atom.
ACTIONS
Norepinephrine bitartrate injection functions as a powerful peripheral
vasoconstrictor (alpha-
adrenergic action) and as a potent inotropic stimulator of the heart
and dilator of coronary
arteries (beta-adrenergic action). Both of these actions result in an
increase in systemic blood
pressure and coronary artery blood flow. Cardiac output will vary
reflexly in response to
systemic hypertension but is usually increased in hypotensive man when
the blood pressure is
raised
to
an
optimal
level.
In
myocardial
infarction
accompanied
by
hypotension.
Norepinephrine bitartrate injection usually increases aortic blood
pressure, coronary artery blood
flow, and myocardial oxygenation, thereby helping to limit the area of
myocardial ischemia and
infarction. Venous return is increased and the heart tends to resume a
more normal rate and
rhythm than in the hypotensive state.
In hypotension that persists after correction of blood volume
deficits, norepinephrine bitartrate
injection helps raise the blood pressure to an optimal level and
establish a more adequate
circulation.
In _myocardial infarction,_ norepinephrine bitartrate injection has
been shown to increase greatly
the patient survival rate. Norepinephrine bitartrate injection not
only corrects systemic shock
(through
cardiotonic
and
peripheral
vasoconstrictor
action),
but
also
markedly
dilates
the
coronary arteries, thereby increasing coronary blood flow, reducing
the area of ischemia and
promoting myocardial oxygenation. The