NOREPINEPHRINE BITARTRATE INJECTION USP SOLUTION

Pays: Canada

Langue: anglais

Source: Health Canada

Ingrédients actifs:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE)

Disponible depuis:

GENERIC MEDICAL PARTNERS INC

Code ATC:

C01CA03

DCI (Dénomination commune internationale):

NOREPINEPHRINE

Dosage:

1MG

forme pharmaceutique:

SOLUTION

Composition:

NOREPINEPHRINE (NOREPINEPHRINE BITARTRATE) 1MG

Mode d'administration:

INTRAVENOUS

Unités en paquet:

15G/50G

Type d'ordonnance:

Ethical

Domaine thérapeutique:

ALPHA-AND BETA-ADRENERGIC AGONISTS

Descriptif du produit:

Active ingredient group (AIG) number: 0131301001; AHFS:

Statut de autorisation:

APPROVED

Date de l'autorisation:

2019-02-08

Résumé des caractéristiques du produit

PRESCRIBING INFORMATION
NOREPINEPHRINE BITARTRATE INJECTION USP
(norepinephrine bitartrate injection USP)
Solution, 1 mg norepinephrine/mL
SYMPATHOMIMETIC AMINE FOR USE IN HYPOTENSIVE EMERGENCIES
Generic Medical Partners Inc.
1500 Don Mills Road, Suite 406
Toronto, ON
M3B 3K4
Date of Revision:
August 18, 2020
Control No. : 241220
2
DESCRIPTION
Norepinephrine (sometimes referred to as _ l-arterenol/Levarterenol or
l-norepinephrine)_ is a
sympathomimetic amine which differs from epinephrine by the absence of
a methyl group on the
nitrogen atom.
ACTIONS
Norepinephrine bitartrate injection functions as a powerful peripheral
vasoconstrictor (alpha-
adrenergic action) and as a potent inotropic stimulator of the heart
and dilator of coronary
arteries (beta-adrenergic action). Both of these actions result in an
increase in systemic blood
pressure and coronary artery blood flow. Cardiac output will vary
reflexly in response to
systemic hypertension but is usually increased in hypotensive man when
the blood pressure is
raised
to
an
optimal
level.
In
myocardial
infarction
accompanied
by
hypotension.
Norepinephrine bitartrate injection usually increases aortic blood
pressure, coronary artery blood
flow, and myocardial oxygenation, thereby helping to limit the area of
myocardial ischemia and
infarction. Venous return is increased and the heart tends to resume a
more normal rate and
rhythm than in the hypotensive state.
In hypotension that persists after correction of blood volume
deficits, norepinephrine bitartrate
injection helps raise the blood pressure to an optimal level and
establish a more adequate
circulation.
In _myocardial infarction,_ norepinephrine bitartrate injection has
been shown to increase greatly
the patient survival rate. Norepinephrine bitartrate injection not
only corrects systemic shock
(through
cardiotonic
and
peripheral
vasoconstrictor
action),
but
also
markedly
dilates
the
coronary arteries, thereby increasing coronary blood flow, reducing
the area of ischemia and
promoting myocardial oxygenation. The