情報リーフレット
Metoprolol Sandoz
®
version 01
1
METOPROLOL SANDOZ
®
METOPROLOL TARTRATE TABLETS
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common questions about Metoprolol Sandoz
®
.
It does not contain all the available information. It does
not take the place of talking to your
doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed
the risk of you taking this
medicine against the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT METOPROLOL SANDOZ
®
IS USED FOR
This medicine is used to treat:
high blood pressure (hypertension).
heart attack (myocardial infarction).
prevent severe chest pain (angina pectoris).
migraine.
It contains the active ingredient metoprolol tartrate.
Metoprolol Sandoz
®
belongs to a group of medicines called beta-blockers.
It works by affecting the body’s response to some nerve impulses, especially in the heart. As a
result, it decreases the heart’s need for blood and oxygen and therefore reduces the amount of
work the heart has to do. It also widens the blood vessels in the body, causing blood pressure to
fall.
ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED
FOR YOU.
Your doctor may have prescribed it for another reason.
There is no evidence that Metoprolol Sandoz
®
is addictive.
This medicine is available only with a doctor’s prescription.
There is not enough information to recommend the use of this
medicine for children.
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製品の特徴
_Product Information _
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_Page 1 _
_Metoprolol Sandoz Tablets – 50mg & 100mg _
_01/2013 _
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_Sandoz Pty Ltd _
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_ Version 02 _
PRODUCT INFORMATION
METOPROLOL SANDOZ
®
50MG AND 100MG TABLETS
NAME OF THE MEDICINE
_Chemical name_: di[(_RS_)-3-[4-(2-methoxyethyl)phenoxy]-1-(isopropylamino)propan-2-ol] tartrate
_Generic name_: Metoprolol tartrate
_Chemical Structure_:
CAS Number: 56392-17-7
(C
15
H
25
NO
3
)
2
.
C
4
H
6
O
6
MW = 684.8
DESCRIPTION
Metoprolol tartrate is a white crystalline powder.
Melting point: approximately 120ºC. The powder is
practically odourless. It is very soluble in water, soluble in
chloroform, methylene chloride and
alcohol, and almost insoluble in benzene,
diethyl ether and acetone.
In addition to metoprolol tartrate, Metoprolol Sandoz
®
tablets also contain lactose, maize starch,
microcrystalline cellulose, magnesium stearate, colloidal anhydrous silica, hydroxypropylcellulose,
calcium hydrogen phosphate and crospovidone.
PHARMACOLOGY
Pharmacodynamics
Metoprolol
tartrate is structurally related to other cardioselective
ß-blockers. It is a relatively
cardioselective ß-adrenoceptor blocking medicine without
intrinsic sympathomimetic activity, and is
suited for the treatment of hypertension. It acts
on ß1-receptors mainly located in the heart at lower
doses than those needed to
influence the ß2-receptors mainly located in the bronchi and
peripheral
vessels. Metoprolol reduces blood pressure in patients with
hypertension, in both the standing and
supine position. It also reduces the
extent of rises in blood pressure occurring in response
to physical
and mental stress. In angina pectoris metoprolol reduces the frequency and severity of the attacks and
the need
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