País: Austràlia
Idioma: anglès
Font: Department of Health (Therapeutic Goods Administration)
Metoprolol tartrate
Sandoz Pty Ltd
Medicine Registered
Metoprolol Sandoz ® version 01 1 METOPROLOL SANDOZ ® METOPROLOL TARTRATE TABLETS CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Metoprolol Sandoz ® . It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you taking this medicine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT METOPROLOL SANDOZ ® IS USED FOR This medicine is used to treat: high blood pressure (hypertension). heart attack (myocardial infarction). prevent severe chest pain (angina pectoris). migraine. It contains the active ingredient metoprolol tartrate. Metoprolol Sandoz ® belongs to a group of medicines called beta-blockers. It works by affecting the body’s response to some nerve impulses, especially in the heart. As a result, it decreases the heart’s need for blood and oxygen and therefore reduces the amount of work the heart has to do. It also widens the blood vessels in the body, causing blood pressure to fall. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. There is no evidence that Metoprolol Sandoz ® is addictive. This medicine is available only with a doctor’s prescription. There is not enough information to recommend the use of this medicine for children. Llegiu el document complet
_Product Information _ _ _ _Page 1 _ _Metoprolol Sandoz Tablets – 50mg & 100mg _ _01/2013 _ _ _ _ _ _Sandoz Pty Ltd _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Version 02 _ PRODUCT INFORMATION METOPROLOL SANDOZ ® 50MG AND 100MG TABLETS NAME OF THE MEDICINE _Chemical name_: di[(_RS_)-3-[4-(2-methoxyethyl)phenoxy]-1-(isopropylamino)propan-2-ol] tartrate _Generic name_: Metoprolol tartrate _Chemical Structure_: CAS Number: 56392-17-7 (C 15 H 25 NO 3 ) 2 . C 4 H 6 O 6 MW = 684.8 DESCRIPTION Metoprolol tartrate is a white crystalline powder. Melting point: approximately 120ºC. The powder is practically odourless. It is very soluble in water, soluble in chloroform, methylene chloride and alcohol, and almost insoluble in benzene, diethyl ether and acetone. In addition to metoprolol tartrate, Metoprolol Sandoz ® tablets also contain lactose, maize starch, microcrystalline cellulose, magnesium stearate, colloidal anhydrous silica, hydroxypropylcellulose, calcium hydrogen phosphate and crospovidone. PHARMACOLOGY Pharmacodynamics Metoprolol tartrate is structurally related to other cardioselective ß-blockers. It is a relatively cardioselective ß-adrenoceptor blocking medicine without intrinsic sympathomimetic activity, and is suited for the treatment of hypertension. It acts on ß1-receptors mainly located in the heart at lower doses than those needed to influence the ß2-receptors mainly located in the bronchi and peripheral vessels. Metoprolol reduces blood pressure in patients with hypertension, in both the standing and supine position. It also reduces the extent of rises in blood pressure occurring in response to physical and mental stress. In angina pectoris metoprolol reduces the frequency and severity of the attacks and the need Llegiu el document complet