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LIGNOCAINE INJECTION
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Lignocaine Injection.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Lignocaine
Injection against the benefits this
medicine is expected to have for you.
This medicine is likely to be used
while you are at the clinic or in
hospital. If possible, please read this
leaflet carefully before this medicine
is given to you. In some cases this
leaflet may be given to you after the
medicine has been used.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT LIGNOCAINE
INJECTION IS USED FOR
Lignocaine Injection belongs to two
groups of medicines known as local
anaesthetics and antiarrhythmic
drugs. Local anaesthetics stop pain
and feeling in the area around where
it is injected; and antiarrhythmic
drugs work by restoring irregular
and/or rapid heart beats to normal.
Lignocaine Injection may be used for
the management of other conditions
that are not mentioned above. Your
doctor will be able to tell you about
the specific condition for which you
have been prescribed Lignocaine
Injection.
This medicine is available only with
a doctor's prescription.
BEFORE YOU ARE GIVEN
LIGNOCAINE INJECTION
_WHEN YOU MUST NOT BE GIVEN_
_IT_
DO NOT USE LIGNOCAINE INJECTION IF:
•
you have an allergy to lignocaine
or any of the ingredients listed at
the end of this leaflet. Symptoms
of an allergic reaction may
include shortness of breath,
wheezing or difficulty breathing,
swelling of the face, lips, tongue
or other parts of the body, rash,
itching or hives on the skin.
•
you have an infection or swelling
where the injection will be given
•
you have blood infections or
disorders
•
you are in severe shock
•
you have low blood pressure
•
you have diseases of
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製品の特徴
Product Information
LIGNOCAINE INJECTION
Page 1 of 10
Version: pfpligni10511
Supersedes: pfpligni
10410
NAME OF DRUG
Lignocaine Hydrochloride.
DESCRIPTION
Lignocaine hydrochloride is 2-diethylamino- 2',6'- dimethylacetanilide hydrochloride monohydrate.
It appears as a white, crystalline powder that is very soluble in water, freely soluble in alcohol and
practically insoluble in ether.
The structural formula is represented below.
(H
5
C
2
)
2
N
CH
2
C
NH
H
3
C
H
3
C
O
, HCl, H
2
O
Molecular Formula:
C
14
H
22
N
2
O,HCl,H
2
O
Molecular Weight:
288.8
CAS Number:
6108-05-0
Lignocaine Injection is a clear, colourless, sterile, isotonic, preservative-free solution containing
Lignocaine Hydrochloride BP 1% or 2% and Sodium Chloride BP in
Water for Injections BP.
PHARMACOLOGY
CLASS: Local anaesthetic of the amide type and antiarrhythmic
drug.
MECHANISM OF ACTION: Lignocaine stabilises all potentially excitable membranes and prevents the
initiation and transmission of nerve impulses. This produces a local anaesthetic effect. Onset of
action is rapid and blockade may last from 60 - 90 minutes. Studies of the effects of therapeutic
concentrations of lignocaine on the
electrophysiological properties of mammalian Purkinje fibers have
shown that lignocaine
attenuates phase 4 diastolic depolarisation,
decreases automaticity, and causes a
decrease or no change in excitability and membrane responsiveness. Action potential duration and
effective refractory period of Purkinje fibers are decreased, while the ratio of effective refractory
period to action potential duration
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