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GA TRAMADOL CAPSULES
_Tramadol hydrochloride_
Page 1 of 3
GA Tramadol V2 100528
CONSUMER
MEDICINE
INFORMATION
_ _
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about GA Tramadol. It
does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking GA
Tramadol against the benefits this
medicine is expected to have for
you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT GA TRAMADOL IS
USED FOR
GA Tramadol is used to relieve
moderate to severe pain and
belongs to a group of medicines
called analgesics (pain relievers).
Your doctor may have prescribed
GA Tramadol for another reason.
Ask your doctor why GA Tramadol
has been prescribed for you.
This medicine is available only with
a doctor's prescription.
GA Tramadol is not normally
addictive although some cases
have been reported.
BEFORE YOU USE GA
TRAMADOL
_When you must not use it _
_ _
Do not use GA Tramadol if:
• YOU HAVE A KNOWN ALLERGY
TO GA TRAMADOL OR ANY
OF THE INGREDIENTS LISTED
AT THE END OF THIS LEAFLET.
Some of the symptoms of
an allergic reaction may
include skin rash, itching,
difficulty breathing and
swelling of the face
(including lips, tongue,
throat etc)
• YOU ARE TAKING MEDICINE
FOR DEPRESSION
CONTAINING A "MONOAMINE
OXIDASE INHIBITOR" (SUCH
AS NARDIL, PARNATE), OR
HAVE TAKEN ONE WITHIN THE
PAST TWO WEEKS.
DO NOT USE GA TRAMADOL AFTER
THE EXPIRY DATE PRINTED ON THE
PACK.
If you take this medicine after the
expiry date has passed, it may not
work as well.
DO NOT USE GA TRAMADOL IF THE
PACKAGING IS TORN OR SHOWS SIGNS
OF TAMPERING.
DO NOT GIVE GA
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製品の特徴
PR
RODUCT
T INFOR
RMATIO
ON
G
GA TRAMA
ADOL 50 M
MG CAPSULEES
NA
AME OF T
THE MEDICINE
The
activ
e product, G
ve ingredien
GA Tramado
nt.
ol 50 mg cap
psules, conttains tramad
dol hydroch
hloride as th
he
Thee chemical sstructure of tramadol hy
ydrochlorid
de is:
[http://www.pharmacopoeia.co.uk/ixbin/bp.cgi?a=imagezoom&file=bp2008_v2_09_medicinal_and_pharmaceutical_substances_09/large/5_tram1.png]
CAS
S number: 3
36282-47-0
DESCRIPTIO
ON AND COMPOS
SITION
The
[(dim
Mol
Tram
read
part
The
cellu
titan
CL
PHA
ami
sour
Tramadol V2
e chemical n
methylamin
lecular form
madol hydr
dily soluble
tition coeffi
e excipients
ulose – mic
nium dioxid
LINICAL P
ARMACODYN
inocyclohex
rces, nor is
100528
name of tram
no)methyl)]
mula: C
16
H
2
rochloride is
in both wat
cient is 1.35
contained i
crocrystallin
de, quinolin
PHARMA
NAMICS: Tram
xanol group
it chemical
madol hydro
-1-(3-metho
ochloride is
oxyphenyl)
s (1_RS_,2_RS_)
cyclohexan
-2-
nol hydrochlloride.
5
NO
2
.HCl. MW: 299.8
84.
s an odourle
ter and etha
5 at pH 7.
ess, white to
anol and has
o off white c
s a pKa of 9
crystalline p
9.41. The w
powder that
ater/n-octan
t is
nol
in the produ
ne, silica – c
e yellow, ir
uct include c
colloidal anh
ron oxide ye
croscarmell
hydrous, m
ellow, Brilli
lose sodium
agnesium st
iant Blue FC
m, povidone,
tearate, gela
CF.
,
atin,
ACOLOGY
Y
madol is a c
with opioid
ly related to
centrally ac
d-like effect
o opiates.
ting synthet
ts. It is not
tic analgesi
derived fro
c of the
om natural
GA T
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Although the mode of action is not completely understood, at least
two
complementary mechanisms appear applicable: binding to _µ_-opioid
receptors and
inhibition of re-uptake of noradrenaline and serotonin. The
opioid like activity of
tramadol derives from low affinity binding of the parent compound
to _µ_-opioid
receptors and higher affinity binding of the princi
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