国: マレーシア
言語: 英語
ソース: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
DILTIAZEM HYDROCHLORIDE
ORION PHARMA (MY) SDN. BHD.
DILTIAZEM HYDROCHLORIDE
100Tablet Tablets
ORION CORP
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ _ _ CARDIL 120MG CONTROLLED RELEASE TABLET _®_ _ _ Diltiazem Hydrochloride (120 mg) 1 WHAT IS IN THIS LEAFLET 1. What Cardil is used for 2. How Cardil works 3. Before you use Cardil 4. How to use Cardil 5. While you are using it 6. Side Effects 7. Storage and Disposal of Cardil 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT CARDIL IS USED FOR Cardil Tablets contain diltiazem hydrochloride, which belongs to a group of medicines called calcium channel blockers. Cardil Tablets are used in the treatment of: mild to moderate high blood pressure angina pectoris (a condition which causes chest pain sometimes on exertion) HOW CARDIL WORKS In high blood pressure, diltiazem hydrochloride works by widening the blood vessels. This creates less resistance to the blood flow, and results in lower blood pressure, which in turn reduces the strain on your heart. In angina, diltiazem hydrochloride works by opening up the arteries supplying the heart muscle and this allows more blood and oxygen to reach the muscle, decreasing the chances of angina ( chest pains ) occurring when extra strain is placed upon the heart. BEFORE YOU USE _- When you must not use it _ Do not take Cardil Tablets if you: are allergic (hypersensitive) to diltiazem hydrochloride or any of the other ingredients of Cardil Tablets (see Section 8 Product Description) have a heart condition which results in an abnormal heart beat causing palpitations or fainting (sick sinus syndrome or second or third degree AV block) and do not have a functioning pacemaker have a heart condition called Wolff-Parkinson-White syndrome and a rapid, irregular heart beat (atrial fibrillation/flutter) have a very slow pulse – less than 40 beats per minute have heart failure with poor blood flow (causing breathlessness, tiredness and ankle swelling) have recently had a heart attack have very low blood pressure are a woman of child bearing age (see 完全なドキュメントを読む
PACKAGE INSERT FOR CARDIL 120 MG CONTROLLED-RELEASED TABLET (FOR MALAYSIA) CARDIL CARDIL 120 mg controlled release tablet PRESENTATION Cardil 120 mg controlled release tablets are white, film-coated, capsule-shaped and scored. Code DL 120. Each tablet contains Diltiazem hydrochloride 120 mg in a controlled-release formulation. PHARMACODYNAMIC PROPERTIES Pharmacotherapeutic group: Benzothiazepine derivatives. ATC-code: C08DB01. Diltiazem is a benzothiazepine derivative that effectively blocks the slow calcium channels (L channels) of vascular smooth muscle and cardiac muscle cells. Slow calcium channels play an important role especially in the regulation of sinoatrial and atrioventricular node function in the cardiac muscle cells. Diltiazem possesses both peripheral and coronary vasodilator properties. However, diltiazem – induced fall in blood pressure is not commonly followed by reflectory tachycardia which is probably due to the depressive effect of the drug on the stimulation of sinoatrial node function. Diltiazem slows atrioventricular conduction. It also has a weak negative inotropic effect on the heart. Diltiazem improves relaxation of the cardiac muscle and diastolic function which together with decreased afterload improves the left ventricular function. In spite of coronary dilatation the total flow in healthy coronary arteries does not usually change, but some improvement in the circulation of contracted arteries has been observed. Diltiazem relaxes smooth muscle also elsewhere in the body, e.g. the lower oesophageal sphincter muscle. Diltiazem has not been shown to have effect on electrolyte-, lipid- or glucose balance in healthy or diabetic persons. Pharmacokinetic properties Diltiazem is completely absorbed after oral administration, but owing to its first- pass metabolism in the liver, the absolute bioavailability of diltiazem hydrochloride is only about 40% (with interindividual variability ranging from 24 to 74%). The bioavailability is independent of formulation or therapeutic dose. A diet rich 完全なドキュメントを読む