情報リーフレット
BUSPAR
– Consumer Medicine Information
Page 1 of 4
BUSPAR
_ _
_buspirone hydrochloride_
CONSUMER MEDICINE INFORMATION (CMI)
_ _
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Buspar. It does not
contain all the available information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and benefits.
Your doctor or pharmacist has
weighed the risks of you taking
Buspar against the benefits they
expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT BUSPAR IS USED FOR
_ _
Buspar is an anxiolytic, a medicine
used to treat anxiety over short
periods of time. The way it works is
unknown. It does not relax muscles
or cause drowsiness in most patients.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY BUSPAR HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another purpose.
There is no evidence that Buspar is
addictive.
This medicine is only available with a
doctor’s prescription.
Buspar is not recommended for use
in children under the age of 18, as
there have not been enough studies
of its effects in children.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT _
DO NOT TAKE BUSPAR IF YOU HAVE AN
ALLERGY TO THE ACTIVE INGREDIENT,
BUSPIRONE HYDROCHLORIDE OR ANY OF
THE TABLET INGREDIENTS LISTED AT THE
END OF THIS LEAFLET.
Symptoms of an allergic reaction may
include:
itchy rash, hives,
完全なドキュメントを読む
製品の特徴
BUSPAR – Product Information
Page 1 of 12
BUSPAR
(buspirone hydrochloride)
Tablets 5 mg & 10 mg
PRODUCT INFORMATION
NAME OF THE MEDICINE
BUSPAR
contains buspirone hydrochloride and chemically is
8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
monohydrochloride. The chemical structure is
CAS No. 33386-08-2
DESCRIPTION
BUSPAR
(buspirone hydrochloride) is an
antianxiety agent that is not chemically or
pharmacologically related to the benzodiazepines but has some
resemblance to drugs which
interact with dopamine receptors.
Buspirone hydrochloride is a white, crystalline, water
soluble compound with a molecular weight of 422.0.
The tablets consist of the active drug in lactose anhydrous,
sodium starch glycollate,
microcrystalline cellulose, colloidal
silicon dioxide and magnesium stearate.
PHARMACOLOGY
PHARMACODYNAMICS
Buspirone hydrochloride belongs chemically to
the class of pharmacologic agents with
selective anxiolytic psychotropic activity known
as the azapirones.
The mechanism of action of buspirone is unknown. In
contrast to the benzodiazepines, and
other anxiolytic agents,
buspirone does not exert anticonvulsant or muscle relaxant effects.
It
also lacks the prominent sedative effect that
is associated with more typical anxiolytics. _In _
_vitro_ preclinical studies have shown
that buspirone has a high affinity for serotonin (5-HT
1A
)
receptors. Buspirone has no
significant affinity for benzodiazepine receptors and does not
affect GABA binding _in vitro_ or _in vivo_ when tested in preclinical
models.
BUSPAR – Product Information
Page 2 of 12
Buspirone has moderate affinity for brain D2-dopamine receptors.
Some studies do suggest
that buspi
完全なドキュメントを読む