Zoletil 100 Injectable Anaesthetic

מדינה: מלזיה

שפה: אנגלית

מקור: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

מרכיב פעיל:

Tiletamine Hydrochloride; Zolazepam Hydrochloride

זמין מ:

PET ARCADE SDN BHD

INN (שם בינלאומי):

Tiletamine Hydrochloride; Zolazepam Hydrochloride

יחידות באריזה:

0.99 mcg/mL

תוצרת:

VIRBAC

מאפייני מוצר

COMPOSITION
Each freeze-dried vial contains
ZOLETIL 100 INJECTABLE ANAESTHETIC:
Tiletamine (as hydrochloride).....250 mg
Zolazepam (as hydrochloride).....250 mg
DESCRIPTION
ZOLETIL is a white to slightly yellow compact mass and a solvent for
reconstitution.
PHARMACODYNAMICS
The combined drugs of ZOLETIL have a complementary mode of action.
Tiletamine is a dissociative anaesthetic agent which is
pharmacologically similar to Ketamine. Zolazepam, on the other hand,
is a benzodiazepine, pharmacologically similar to diazepam.
It is a sedative, an anxiolytic and a muscle relaxant. Zolazepam
enhances the Tiletamine depression of the central nervous
system. It also prevents the seizures due to Tiletamine and improves
both muscle relaxation and emergence from anaesthesia.
ZOLETIL produces an anaesthetic effect which does not correspond to
any conventional anaesthetic state. It produces a state of
unconsciousness that has been referred to as dissiociative because it
appears to selectively interrupt association pathways to the
brain before provoking anaesthetic sensory blockage. Analgesia results
from the apparent selective interruption of sensory inputs
to the brain.
Depending of the animal species, analgesia persists after the
anaesthetic effect has subsided. In a great majority of the animals
and unless the product is used at extremely high doses, pharyngeal and
laryngeal reflexes remain intact. Cranial nerves and
spinal reflexes remain intact. Consequently, the animal’s eyes
remain open and the animal can swallow, move its tongue, chew,
blink its eyelids and move its limbs during the anaesthesia. The fact
that all of these reflexes persist is not an indication that the
anaesthesia is inadequate.
The actions of ZOLETIL can be summarised as follows :
Catalepsy :
- rapid, without agitation, followed by muscular relaxation.
Analgesia :
- immediate superficial analgesia
- moderate visceral analgesia
Surgical anaesthesia :
- with muscular relaxation
- persistence of laryngeal, pharyngeal and palpebral reflexes
- no depressi