Maa: Malesia
Kieli: englanti
Lähde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Tiletamine Hydrochloride; Zolazepam Hydrochloride
PET ARCADE SDN BHD
Tiletamine Hydrochloride; Zolazepam Hydrochloride
0.99 mcg/mL
VIRBAC
COMPOSITION Each freeze-dried vial contains ZOLETIL 100 INJECTABLE ANAESTHETIC: Tiletamine (as hydrochloride).....250 mg Zolazepam (as hydrochloride).....250 mg DESCRIPTION ZOLETIL is a white to slightly yellow compact mass and a solvent for reconstitution. PHARMACODYNAMICS The combined drugs of ZOLETIL have a complementary mode of action. Tiletamine is a dissociative anaesthetic agent which is pharmacologically similar to Ketamine. Zolazepam, on the other hand, is a benzodiazepine, pharmacologically similar to diazepam. It is a sedative, an anxiolytic and a muscle relaxant. Zolazepam enhances the Tiletamine depression of the central nervous system. It also prevents the seizures due to Tiletamine and improves both muscle relaxation and emergence from anaesthesia. ZOLETIL produces an anaesthetic effect which does not correspond to any conventional anaesthetic state. It produces a state of unconsciousness that has been referred to as dissiociative because it appears to selectively interrupt association pathways to the brain before provoking anaesthetic sensory blockage. Analgesia results from the apparent selective interruption of sensory inputs to the brain. Depending of the animal species, analgesia persists after the anaesthetic effect has subsided. In a great majority of the animals and unless the product is used at extremely high doses, pharyngeal and laryngeal reflexes remain intact. Cranial nerves and spinal reflexes remain intact. Consequently, the animal’s eyes remain open and the animal can swallow, move its tongue, chew, blink its eyelids and move its limbs during the anaesthesia. The fact that all of these reflexes persist is not an indication that the anaesthesia is inadequate. The actions of ZOLETIL can be summarised as follows : Catalepsy : - rapid, without agitation, followed by muscular relaxation. Analgesia : - immediate superficial analgesia - moderate visceral analgesia Surgical anaesthesia : - with muscular relaxation - persistence of laryngeal, pharyngeal and palpebral reflexes - no depressi Lue koko asiakirja