מדינה: ארצות הברית
שפה: אנגלית
מקור: NLM (National Library of Medicine)
TRIAMCINOLONE ACETONIDE (UNII: F446C597KA) (TRIAMCINOLONE ACETONIDE - UNII:F446C597KA)
Par Pharmaceutical
TOPICAL
PRESCRIPTION DRUG
Triamcinolone acetonide lotion 0.1% is indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.
Triamcinolone Acetonide Lotion, USP 0.1%: plastic squeeze bottles containing 60 mL of lotion Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature]. Avoid freezing.
Abbreviated New Drug Application
TRIAMCINOLONE ACETONIDE- TRIAMCINOLONE ACETONIDE LOTION PAR PHARMACEUTICAL ---------- TRIAMCINOLONE ACETONIDE LOTION, USP 0.1% RX ONLY DESCRIPTION The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. The steroids in this class include triamcinolone acetonide. Triamcinolone acetonide is designated chemically as 9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20- dione cyclic 16,17-acetal with acetone. Graphic formula: Each mL of 0.1% triamcinolone acetonide lotion provides 1 mg triamcinolone acetonide in a lotion base containing cetyl alcohol, citric acid, polysorbate 20, propylene glycol, purified water, simethicone 30% emulsion, sorbitan monopalmitate and stearyl alcohol. CLINICAL PHARMACOLOGY Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man. PHARMACOKINETICS The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses (see DOSAGE AND ADMINISTRATION). Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are boun קרא את המסמך השלם