TRIAMCINOLONE ACETONIDE- triamcinolone acetonide lotion

Ülke: ABD

Dil: İngilizce

Kaynak: NLM (National Library of Medicine)

Aktif bileşen:

TRIAMCINOLONE ACETONIDE (UNII: F446C597KA) (TRIAMCINOLONE ACETONIDE - UNII:F446C597KA)

Mevcut itibaren:

Par Pharmaceutical

Uygulama yolu:

TOPICAL

Reçete türü:

PRESCRIPTION DRUG

Terapötik endikasyonlar:

Triamcinolone acetonide lotion 0.1% is indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.

Ürün özeti:

Triamcinolone Acetonide Lotion, USP 0.1%: plastic squeeze bottles containing 60 mL of lotion Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature]. Avoid freezing.

Yetkilendirme durumu:

Abbreviated New Drug Application

Ürün özellikleri

TRIAMCINOLONE ACETONIDE- TRIAMCINOLONE ACETONIDE LOTION
PAR PHARMACEUTICAL
----------
TRIAMCINOLONE ACETONIDE LOTION, USP
0.1%
RX ONLY
DESCRIPTION
The topical corticosteroids constitute a class of primarily synthetic
steroids used as anti-inflammatory
and antipruritic agents. The steroids in this class include
triamcinolone acetonide. Triamcinolone
acetonide is designated chemically as
9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-
dione cyclic 16,17-acetal with acetone.
Graphic formula:
Each mL of 0.1% triamcinolone acetonide lotion provides 1 mg
triamcinolone acetonide in a lotion base
containing cetyl alcohol, citric acid, polysorbate 20, propylene
glycol, purified water, simethicone
30% emulsion, sorbitan monopalmitate and stearyl alcohol.
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, antipruritic and
vasoconstrictive actions.
The mechanism of anti-inflammatory activity of the topical
corticosteroids is unclear. Various
laboratory methods, including vasoconstrictor assays, are used to
compare and predict potencies and/or
clinical efficacies of the topical corticosteroids. There is some
evidence to suggest that a
recognizable correlation exists between vasoconstrictor potency and
therapeutic efficacy in man.
PHARMACOKINETICS
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
including the vehicle, the integrity of the epidermal barrier, and the
use of occlusive dressings.
Topical corticosteroids can be absorbed from normal intact skin.
Inflammation and/or other disease
processes in the skin increase percutaneous absorption. Occlusive
dressings substantially increase the
percutaneous absorption of topical corticosteroids. Thus, occlusive
dressings may be a valuable
therapeutic adjunct for treatment of resistant dermatoses (see DOSAGE
AND ADMINISTRATION).
Once absorbed through the skin, topical corticosteroids are handled
through pharmacokinetic pathways
similar to systemically administered corticosteroids. Corticosteroids
are boun