TRANPAM TABLET 1MG

מדינה: מלזיה

שפה: אנגלית

מקור: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

מרכיב פעיל:

LORAZEPAM

זמין מ:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

INN (שם בינלאומי):

LORAZEPAM

יחידות באריזה:

1000 Tablets

תוצרת:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

עלון מידע

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
__________________________________________________________________________________________________________
1
TRANPAM TABLET
Lorazepam (0.5mg and 1mg)
WHAT IS IN THIS LEAFLET:
1.
What Tranpam Tablet is used for
2.
How Tranpam Tablet works
3.
Before you use Tranpam Tablet
4.
How to use Tranpam Tablet
5.
While
you
are
using
Tranpam
Tablet
6.
Side Effects
7.
Storage and Disposal of Tranpam
Tablet
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of Revision
WHAT TRANPAM TABLET IS USED FOR
Lorazepam is the active
ingredient of
Tranpam Tablet 0.5mg or 1mg.
It
is
indicated
for
the
treatment
of
anxiety and tension states, as a sedative
premedicant
(before
surgery),
in
the
control of muscle spasm as in tetanus
and
in
the
management
of
alcohol
withdrawal symptoms.
HOW TRANPAM TABLET WORKS?
Lorazepam
is
a
short
acting
benzodiazepine. It has a more specific
antianxiety
effect
than
other
sedatives
such as barbiturates. It also possesses
anticonvulsant, sedative, muscle relaxant
and amnesic properties.
It
is
a
benzodiazepine
which
acts
on
chemicals in the brain.
BEFORE YOU TAKE TRANPAM TABLET
_- When you must not use it _

If you have known hypersensitivity
to
Lorazepam
or
any
other
ingredients of Tranpam Tablet.

If you have known hypersensitivity
to benzodiazepines

If you have an eye problem called
acute narrow-angled glaucoma.

If
you
are
pregnant
or
a
nursing
mother.

If
you
have
pre-exisiting
central
nervous system depression or coma

If
you
have
myasthenia
gravis
(a
disease which causes severe muscle
weakness),
severe
liver
problem,
severe
lung
problem
or
stop
breathing
during
sleep
(sleep
apnoea).
_- Before you start to use it _
You must tell your doctor if:

you have allergies to any medicine
which you have taken previously to
treat your current condition.

you are pregnant, trying to become
pregnant or breast-feeding.
_- Taking other medicines _
Please tell your doctor or pharmacist if
you are taking or have recen

מאפייני מוצר

7036-07
TRANPAM TABLET 0.5MG
TRANPAM TABLET 1MG
NAME AND STRENGTH OF ACTIVE SUBSTANCE:
TRANPAM TABLET 0.5MG
Each tablet contains:
Lorazepam………………………………………………0.5mg
TRANPAM TABLET 1MG
Each tablet contains:
Lorazepam………………………………………………1mg
PRODUCT DESCRIPTION:
TRANPAM TABLET 0.5MG
A greenish-blue, round, scored of diameter 7mm flat tablet with MPI
marking.
TRANPAM TABLET 1MG
A blue, round, scored of diameter 7mm, flat tablet with MPI marking.
PHARMACODYNAMICS
:
Lorazepam is a short-acting benzodiazepine. It has a more specific
anxiolytic effect than other sedatives such as
barbiturates. It also possesses anticonvulsant, sedative, muscle
relaxant and amnesic properties. It is believed that
benzodiazepines enhance or facilitate the inhibitory neurotransmitter
action of gamma-aminobutyric acid (GABA), which
mediated both pre- and post-synaptic inhibition in all regions of the
central nervous system, following interaction between
the benzodiazepine and a specific neuronal membrane receptor.
PHARMACOKINETICS:
Lorazepam is rapidly absorbed after oral administration with a
bioavailability of about 90%; peak plasma levels after a 2mg
dose are about 20ng/ml and maximal clinical effects occur within 2
hours after administration. Its mean plasma half-life is
about 12 hours, whereas that of its conjugated metabolites, lorazepam
glucoronide, is about 18 hours. Lorazepam is
metabolised in the liver to the inactive glucoronide, and excreted in
the urine. Approximately 85% is bound to plasma
proteins. There is no evidence of accumulation of lorazepam on
administration for up to 6 months. Lorazepam crosses the
blood-brain barrier and the placenta; it is also excreted in breast
milk.
INDICATION:
It is used in the treatment of anxiety and tension states. As a
sedative premedicant, in the control of muscle spasm, as in
tetanus, and in the management of alcohol withdrawal symptoms.
RECOMMENDED DOSAGE:
i)
Adults: Anxiety : 1-4 mg daily in 2 to 3 divided doses with the