Maa: Malesia
Kieli: englanti
Lähde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
LORAZEPAM
MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.
LORAZEPAM
1000 Tablets
MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ __________________________________________________________________________________________________________ 1 TRANPAM TABLET Lorazepam (0.5mg and 1mg) WHAT IS IN THIS LEAFLET: 1. What Tranpam Tablet is used for 2. How Tranpam Tablet works 3. Before you use Tranpam Tablet 4. How to use Tranpam Tablet 5. While you are using Tranpam Tablet 6. Side Effects 7. Storage and Disposal of Tranpam Tablet 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT TRANPAM TABLET IS USED FOR Lorazepam is the active ingredient of Tranpam Tablet 0.5mg or 1mg. It is indicated for the treatment of anxiety and tension states, as a sedative premedicant (before surgery), in the control of muscle spasm as in tetanus and in the management of alcohol withdrawal symptoms. HOW TRANPAM TABLET WORKS? Lorazepam is a short acting benzodiazepine. It has a more specific antianxiety effect than other sedatives such as barbiturates. It also possesses anticonvulsant, sedative, muscle relaxant and amnesic properties. It is a benzodiazepine which acts on chemicals in the brain. BEFORE YOU TAKE TRANPAM TABLET _- When you must not use it _ If you have known hypersensitivity to Lorazepam or any other ingredients of Tranpam Tablet. If you have known hypersensitivity to benzodiazepines If you have an eye problem called acute narrow-angled glaucoma. If you are pregnant or a nursing mother. If you have pre-exisiting central nervous system depression or coma If you have myasthenia gravis (a disease which causes severe muscle weakness), severe liver problem, severe lung problem or stop breathing during sleep (sleep apnoea). _- Before you start to use it _ You must tell your doctor if: you have allergies to any medicine which you have taken previously to treat your current condition. you are pregnant, trying to become pregnant or breast-feeding. _- Taking other medicines _ Please tell your doctor or pharmacist if you are taking or have recen Lue koko asiakirja
7036-07 TRANPAM TABLET 0.5MG TRANPAM TABLET 1MG NAME AND STRENGTH OF ACTIVE SUBSTANCE: TRANPAM TABLET 0.5MG Each tablet contains: Lorazepam………………………………………………0.5mg TRANPAM TABLET 1MG Each tablet contains: Lorazepam………………………………………………1mg PRODUCT DESCRIPTION: TRANPAM TABLET 0.5MG A greenish-blue, round, scored of diameter 7mm flat tablet with MPI marking. TRANPAM TABLET 1MG A blue, round, scored of diameter 7mm, flat tablet with MPI marking. PHARMACODYNAMICS : Lorazepam is a short-acting benzodiazepine. It has a more specific anxiolytic effect than other sedatives such as barbiturates. It also possesses anticonvulsant, sedative, muscle relaxant and amnesic properties. It is believed that benzodiazepines enhance or facilitate the inhibitory neurotransmitter action of gamma-aminobutyric acid (GABA), which mediated both pre- and post-synaptic inhibition in all regions of the central nervous system, following interaction between the benzodiazepine and a specific neuronal membrane receptor. PHARMACOKINETICS: Lorazepam is rapidly absorbed after oral administration with a bioavailability of about 90%; peak plasma levels after a 2mg dose are about 20ng/ml and maximal clinical effects occur within 2 hours after administration. Its mean plasma half-life is about 12 hours, whereas that of its conjugated metabolites, lorazepam glucoronide, is about 18 hours. Lorazepam is metabolised in the liver to the inactive glucoronide, and excreted in the urine. Approximately 85% is bound to plasma proteins. There is no evidence of accumulation of lorazepam on administration for up to 6 months. Lorazepam crosses the blood-brain barrier and the placenta; it is also excreted in breast milk. INDICATION: It is used in the treatment of anxiety and tension states. As a sedative premedicant, in the control of muscle spasm, as in tetanus, and in the management of alcohol withdrawal symptoms. RECOMMENDED DOSAGE: i) Adults: Anxiety : 1-4 mg daily in 2 to 3 divided doses with the Lue koko asiakirja