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VINCRISTINE SULFATE
INJECTION
_Vincristine Sulfate_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Vincristine Sulfate
Injection. It does not contain all the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Vincristine
Sulfate Injection against the benefits
this medicine is expected to have for
you.
This medicine is likely to be used
while you are at the clinic or in
hospital. If possible, please read this
leaflet carefully before this medicine
is given to you. In some cases this
leaflet may be given to you after the
medicine has been used.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR, NURSE OR PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT VINCRISTINE
SULFATE INJECTION IS
USED FOR
Vincristine sulfate belongs to a group
of anticancer medicines called Vinca
alkaloids. It is used for the treatment
of various cancers. Vincristine stops
the cancer cells growing and
eventually kills them.
BEFORE YOU ARE GIVEN
VINCRISTINE SULFATE
INJECTION
_WHEN YOU MUST NOT BE GIVEN_
_IT_
DO NOT USE VINCRISTINE SULFATE
INJECTION IF:
•
you have an allergy to vincristine
or any of the ingredients listed at
the end of this leaflet
•
you have an allergy to any of the
Vinca Alkaloids medicines eg
Vinblastine and Vindesine
•
you suffer from Charcot-Marie-
Tooth-Syndrome. This is a type
of hereditary nerve disease.
•
you are receiving or have
received radiation therapy
If you are not sure whether any of
these apply to you, check with your
doctor.
_BEFORE YOU ARE GIVEN IT_
TELL YOUR DOCTOR IF:
1. YOU HAVE ANY ALLERGIES TO:
•
any other medicine
•
any other substances, such as
foods, preservatives or dyes
2. YOU ARE PREGNANT OR INTEND TO
BECOME PREGNANT
3. YOU ARE BREASTFEEDING OR PLAN TO
BREASTFEED
4. YOU HAVE OR HAVE HAD ANY
MEDICAL CONDITIONS, ESPECIALLY
THE FOLLOWING:
•
Gout
•
Kid
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Product Information
VINCRISTINE SULFATE INJECTION
PAGE 1 OF 8
Version: pfpvinci10811
Supersedes: pfpvincr10206
Page 1 of 8
NAME OF DRUG
Vincristine Sulfate.
DESCRIPTION
Vincristine Sulfate is the salt of an alkaloid obtained from the
periwinkle plant Vinca rosea
(Catharanthus roseus).
Vincristine Sulfate Injection is a sterile, hypertonic, preservative-free solution
containing Vincristine
Sulfate 1mg/mL and Mannitol in Water for Injections.
Structural Formula:
H
H
,H
2
SO
4
OH
CH
3
O
C
O
O
HO
H
H
3
CO
O
OCH
3
C
H
C
N
N
N
N
CH
3
CH
2
H
CH
2
CH
3
C
O
OCH
3
H
Molecular formula:
C
46
H
56
N
4
O
10
,H
2
SO
4
Molecular weight:
923.1
CAS No.:
2068-78-2
PHARMACOLOGY
CLASS OF DRUG:
Antineoplastic agent. Antimitotic.
MECHANISM OF ACTION:
The precise mechanism of action of vincristine sulfate remains
under investigation. Vincristine
appears to affect cell mitosis
by interfering with microtubular proteins and causing an arrest of cell
division during the metaphase. It is cell cycle phase specific.
PHARMACOKINETICS:
_Distribution:_ After intravenous administration,
vincristine is rapidly distributed to body tissues.
Vincristine is extensively protein bound (75%) and is reported
to be concentrated in blood platelets.
Vincristine does not penetrate the central nervous
system to any significant degree.
_Metabolism and
Excretion:_ Vincristine is extensively metabolised in the
liver. The main route of
elimination is via the bile into the faeces. About 80% of an
injected dose of vincristine appears in the
faeces and 10-20% is excreted in the urine.
INDICATIONS
Vincristine is used primarily in the treatment of acute
leukaemia, usually as a component of various
chemotherapeutic regimens. It has also been used as
part of combination therapy in the treatment of
Hodgkin’s d
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