Land: Australië
Taal: Engels
Bron: Department of Health (Therapeutic Goods Administration)
Vincristine sulfate
VINCRISTINE SULFATE INJECTION _Vincristine Sulfate_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Vincristine Sulfate Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Vincristine Sulfate Injection against the benefits this medicine is expected to have for you. This medicine is likely to be used while you are at the clinic or in hospital. If possible, please read this leaflet carefully before this medicine is given to you. In some cases this leaflet may be given to you after the medicine has been used. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR, NURSE OR PHARMACIST. KEEP THIS LEAFLET. You may need to read it again. WHAT VINCRISTINE SULFATE INJECTION IS USED FOR Vincristine sulfate belongs to a group of anticancer medicines called Vinca alkaloids. It is used for the treatment of various cancers. Vincristine stops the cancer cells growing and eventually kills them. BEFORE YOU ARE GIVEN VINCRISTINE SULFATE INJECTION _WHEN YOU MUST NOT BE GIVEN_ _IT_ DO NOT USE VINCRISTINE SULFATE INJECTION IF: • you have an allergy to vincristine or any of the ingredients listed at the end of this leaflet • you have an allergy to any of the Vinca Alkaloids medicines eg Vinblastine and Vindesine • you suffer from Charcot-Marie- Tooth-Syndrome. This is a type of hereditary nerve disease. • you are receiving or have received radiation therapy If you are not sure whether any of these apply to you, check with your doctor. _BEFORE YOU ARE GIVEN IT_ TELL YOUR DOCTOR IF: 1. YOU HAVE ANY ALLERGIES TO: • any other medicine • any other substances, such as foods, preservatives or dyes 2. YOU ARE PREGNANT OR INTEND TO BECOME PREGNANT 3. YOU ARE BREASTFEEDING OR PLAN TO BREASTFEED 4. YOU HAVE OR HAVE HAD ANY MEDICAL CONDITIONS, ESPECIALLY THE FOLLOWING: • Gout • Kid Lees het volledige document
Product Information VINCRISTINE SULFATE INJECTION PAGE 1 OF 8 Version: pfpvinci10811 Supersedes: pfpvincr10206 Page 1 of 8 NAME OF DRUG Vincristine Sulfate. DESCRIPTION Vincristine Sulfate is the salt of an alkaloid obtained from the periwinkle plant Vinca rosea (Catharanthus roseus). Vincristine Sulfate Injection is a sterile, hypertonic, preservative-free solution containing Vincristine Sulfate 1mg/mL and Mannitol in Water for Injections. Structural Formula: H H ,H 2 SO 4 OH CH 3 O C O O HO H H 3 CO O OCH 3 C H C N N N N CH 3 CH 2 H CH 2 CH 3 C O OCH 3 H Molecular formula: C 46 H 56 N 4 O 10 ,H 2 SO 4 Molecular weight: 923.1 CAS No.: 2068-78-2 PHARMACOLOGY CLASS OF DRUG: Antineoplastic agent. Antimitotic. MECHANISM OF ACTION: The precise mechanism of action of vincristine sulfate remains under investigation. Vincristine appears to affect cell mitosis by interfering with microtubular proteins and causing an arrest of cell division during the metaphase. It is cell cycle phase specific. PHARMACOKINETICS: _Distribution:_ After intravenous administration, vincristine is rapidly distributed to body tissues. Vincristine is extensively protein bound (75%) and is reported to be concentrated in blood platelets. Vincristine does not penetrate the central nervous system to any significant degree. _Metabolism and Excretion:_ Vincristine is extensively metabolised in the liver. The main route of elimination is via the bile into the faeces. About 80% of an injected dose of vincristine appears in the faeces and 10-20% is excreted in the urine. INDICATIONS Vincristine is used primarily in the treatment of acute leukaemia, usually as a component of various chemotherapeutic regimens. It has also been used as part of combination therapy in the treatment of Hodgkin’s d Lees het volledige document