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INDICATIONS [/za_1287.html#1]
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CONTRA-INDICATIONS [/za_1287.html#1]
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DOSAGE [/za_1287.html#1]
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SIDE-EFFECTS [/za_1287.html#1]
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IDENTIFICATION [/za_1287.html#1]
[/za_1287.html#1] PATIENT INFORMATION
IMODIUM PLUS™
© J-C 2000
SCHEDULING STATUS:
Schedule 2
PROPRIETARY NAME
(and dosage form):
IMODIUM PLUS™
CHEWABLE TABLETS.
COMPOSITION
Each chewable tablet contains 2 mg
LOPERAMIDE
hydrochloride and 125 mg
SIMETHICONE
.
PHARMACOLOGICAL CLASSIFICATION
A.11.9 2 Medicines acting on gastro-intestinal tract. Other.
PHARMACOLOGICAL ACTION
Loperamide hydrochloride inhibits hypermotility by direct action on the bowel wall. Its inhibition of peristalsis is the
result of decreasing the activity of both the longitudinal muscles (preparatory and reflex phases) and the circular
muscles (reflex phase).
Loperamide hydrochloride normalises the stool in acute diarrhoea.
Loperamide hydrochloride is incompletely absorbed from the gut, and it is almost completely metabolised in the liver
where it is conjugated and excreted via the bile. Loperamide hydrochloride is mainly eliminated via the faeces.
Simethicone is a nonabsorbable inert surface acting agent with antifoaming properties.
INDICATIONS
ADULTS AND CHILDREN 12 YEARS AND OLDER
IMODIUM Plus is indicated for the control and symptomatic relief of acute and chronic non-specific diarrhoea and its
commonly associated symptoms: discomfort, bloating, cramping and flatulence. It also inhibits peristalsis and slow
intestinal transit time in patients with ileostomies, colostomies and other intestinal resections.
CONTRA-INDICATIONS
IMODIUM Plus is
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