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HYDOPA
_contains the active ingredient methyldopa_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Hydopa.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Hydopa against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT HYDOPA IS USED
FOR
Hydopa is used to lower high blood
pressure, also called hypertension.
Everyone had blood pressure. This
pressure helps get your blood all
around your body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
hypertension (high blood pressure)
when your blood pressure stays
higher than is needed, even when you
are calm and relaxed.
There are usually no symptoms of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. If high
blood pressure is not treated it can
lead to serious health problems. You
may feel fine and have no symptoms,
but eventually hypertension can
cause stroke, heart disease and
kidney failure. Hydopa helps to
lower your blood pressure.
Hydopa works by controlling
impulses along certain nerve
pathways and as a result, widens
blood vessels so that blood passes
through them more easily. This helps
to lower blood pressure.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY HYDOPA HAS
BEEN PRESCRIBED FOR YOU.
Your doctor may have prescribed
Hydopa for another reason.
There is no evidence that Hydopa is
addictive.
Hydopa is available only with a
doctor's prescription.
BEFORE YOU TAKE
HYDOPA
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE HYDOPA IF YOU ARE
ALLERGIC TO:
•
MEDICINES CONTAINING
METHYLDOPA (E.G. ALDOMET)
•
ANY OF THE INGREDIENTS LISTED AT
THE
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产品特点
HYDOPA
_Methyldopa_
PRODUCT INFORMATION
NAME OF THE DRUG
The active ingredient of Hydopa is methyldopa, which is the
L-isomer of
α-methyldopa. Methyldopa is the
sesquihydrate of
(-)-3-(3,4-dihydroxyphenyl)-2-methyl-L-alanine. The structural
formula for methyldopa is:-
HO
HO
COOH
Me
NH
2
Empirical formula: C
10
H
13
NO
4
,1½H
2
O
Molecular weight: 238.2
CAS number: 41372-08-1
DESCRIPTION
Methyldopa is a white to yellowish-white crystalline powder or almost
colourless crystals. It is odourless and
almost tasteless. It is slightly soluble in water and in ethanol
(96%), and is practically insoluble in ether and in
chloroform. It dissolves in dilute mineral acids.
Each Hydopa tablet contains methyldopa equivalent
to 250 mg of anhydrous methyldopa. The tablets also
contain anhydrous citric acid, disodium edetate, ethylcellulose,
sodium starch glycollate, guar gum, colloidal
anhydrous silica, magnesium stearate and Opadry Yellow OY-8462.
PHARMACOLOGY
Methyldopa is an effective antihypertensive agent that decreases both
supine and standing blood pressure.
Symptomatic postural hypotension, exercise hypotension and diurnal
blood pressure variations rarely occur. By
adjustment of dosage, morning hypotension can be prevented without
sacrificing control of afternoon blood
pressure.
Because of relative freedom from adverse
effects on kidney function, methyldopa can be of benefit in the
control
of high blood pressure, even in the presence of renal impairment. It
may help arrest or slow the progression of
renal function impairment and damage due to sustained elevation of
blood pressure.
Normal or elevated plasma renin activity may reduce in the course of
methyldopa therapy.
Methyldopa has no direct effect on cardiac function
and usually does not decrease glomerular filtration rate,
filtration fraction, or renal blood flow. Cardiac output is
usually maintained
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