País: Austrália
Língua: inglês
Origem: Department of Health (Therapeutic Goods Administration)
Methyldopa
HYDOPA _contains the active ingredient methyldopa_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Hydopa. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Hydopa against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, TALK TO YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH YOUR MEDICINE. You may need to read it again. WHAT HYDOPA IS USED FOR Hydopa is used to lower high blood pressure, also called hypertension. Everyone had blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems. You may feel fine and have no symptoms, but eventually hypertension can cause stroke, heart disease and kidney failure. Hydopa helps to lower your blood pressure. Hydopa works by controlling impulses along certain nerve pathways and as a result, widens blood vessels so that blood passes through them more easily. This helps to lower blood pressure. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY HYDOPA HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed Hydopa for another reason. There is no evidence that Hydopa is addictive. Hydopa is available only with a doctor's prescription. BEFORE YOU TAKE HYDOPA _WHEN YOU MUST NOT TAKE IT_ DO NOT TAKE HYDOPA IF YOU ARE ALLERGIC TO: • MEDICINES CONTAINING METHYLDOPA (E.G. ALDOMET) • ANY OF THE INGREDIENTS LISTED AT THE Leia o documento completo
HYDOPA _Methyldopa_ PRODUCT INFORMATION NAME OF THE DRUG The active ingredient of Hydopa is methyldopa, which is the L-isomer of α-methyldopa. Methyldopa is the sesquihydrate of (-)-3-(3,4-dihydroxyphenyl)-2-methyl-L-alanine. The structural formula for methyldopa is:- HO HO COOH Me NH 2 Empirical formula: C 10 H 13 NO 4 ,1½H 2 O Molecular weight: 238.2 CAS number: 41372-08-1 DESCRIPTION Methyldopa is a white to yellowish-white crystalline powder or almost colourless crystals. It is odourless and almost tasteless. It is slightly soluble in water and in ethanol (96%), and is practically insoluble in ether and in chloroform. It dissolves in dilute mineral acids. Each Hydopa tablet contains methyldopa equivalent to 250 mg of anhydrous methyldopa. The tablets also contain anhydrous citric acid, disodium edetate, ethylcellulose, sodium starch glycollate, guar gum, colloidal anhydrous silica, magnesium stearate and Opadry Yellow OY-8462. PHARMACOLOGY Methyldopa is an effective antihypertensive agent that decreases both supine and standing blood pressure. Symptomatic postural hypotension, exercise hypotension and diurnal blood pressure variations rarely occur. By adjustment of dosage, morning hypotension can be prevented without sacrificing control of afternoon blood pressure. Because of relative freedom from adverse effects on kidney function, methyldopa can be of benefit in the control of high blood pressure, even in the presence of renal impairment. It may help arrest or slow the progression of renal function impairment and damage due to sustained elevation of blood pressure. Normal or elevated plasma renin activity may reduce in the course of methyldopa therapy. Methyldopa has no direct effect on cardiac function and usually does not decrease glomerular filtration rate, filtration fraction, or renal blood flow. Cardiac output is usually maintained Leia o documento completo