资料单张
GENRX SALBUTAMOL INHALATION AMPOULE
1
GENRX SALBUTAMOL
INHALATION AMPOULES
_Contains the active
ingredient salbutamol (sal-bew-tam-ol) sulphate _
CONSUMER MEDICINE INFORMATION
_FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055 _
WHAT YOU NEED TO
KNOW ABOUT GENRX
SALBUTAMOL INHALATION
AMPOULES
Your doctor has weighed the risks
and expected benefits of salbutamol
and decided to prescribe this
medicine to help treat your condition,
or the condition of someone you are
caring for.
Read this leaflet carefully before you
start to take this medicine. It contains
important information.
KEEP THE LEAFLET IN A SAFE PLACE
BECAUSE YOU MAY WANT TO READ IT
AGAIN.
If you have any other questions, or if
there is something you don't
understand please ask your doctor or
pharmacist for advice.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
This medicine has been prescribed
for you. You should never give it to
anyone else. It may not be the right
medicine for them even if their
symptoms seem to be the same as
yours.
If you develop any side effects that
are serious or if you notice any side
effects that are not listed in this
leaflet, tell your doctor or pharmacist
immediately or go to the nearest
hospital. Also look at Section 4:
"Possible side effects".
This medicine is only part of a
general plan to help you to manage
your asthma or other breathing
conditions. You should discuss this
plan with your doctor. Ask your
doctor to check your treatment plan
regularly.
_WHAT IS IN THIS LEAFLET _
1. WHAT GENRX SALBUTAMOL
INHALATION AMPOULES ARE FOR
2. THINGS TO CONSIDER BEFORE YOU
USE GENRX SALBUTAMOL
INHALATION AMPOULES
3. HOW TO USE THIS MEDICINE
4. POSSIBLE SIDE EFFECTS
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产品特点
Product Information
– Australia
GENRX SALBUTAMOL INHALATION AMPOULE
Page 1
GENRX SALBUTAMOL INHALATION AMPOULE
NAME OF THE MEDICINE
Salbutamol sulfate.
Chemical Name:
di[(RS)-2-(1,1-dimethyl)ethylamino-1-[4-hydroxy-3-
(hydroxymethyl)phenyl]ethanol] sulfate.
Structural Formula:
HO
HO
N
OH
H
CH
3
CH
3
CH
3
2
.
H
2
SO
4
Molecular Formula:
(C
13
H
21
NO
3
)
2
.H
2
SO
4
Molecular Weight:
576.7
CAS Registry Number: 51022-70-9
DESCRIPTION
Salbutamol sulfate is a white or almost white, odourless powder with a slightly bitter taste. It is freely
soluble in water; slightly soluble in alcohol, chloroform and ether, very slightly soluble in methylene
chloride. Salbutamol sulfate 1.2 mg is approximately equivalent
to 1 mg salbutamol.
PHARMACOLOGY
Salbutamol is a
β
2
-adrenoreceptor agonist.
PHARMACOKINETICS
Absorption
Following inhalation of salbutamol the onset of action is 5 to 15 minutes. Only 10 to 20% of the dose
reaches the lungs, the remainder stays in the mouth, stomach or on the apparatus. Salbutamol
reaching the lungs acts rapidly and directly on bronchial smooth muscle. Initially, the drug is
undetectable in blood but after two to three hours, low concentrations are seen, due presumably to the
portion of the dose which is swallowed and absorbed by the
gut.
Distribution
Salbutamol is not bound to plasma proteins.
Metabolism
The major metabolite of salbutamol, recovered fr
om urine, has been identified as the 4’-o-sulfate ester.
This metabolite has negligible
β-stimulant activity. Salbutamol is not metabolised in the lung and the
pattern of metabolism and excretion (as well as absorption) suggest tha
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