资料单张
DBL
™
Dobutamine Hydrochloride Injection CMI
Page 1
DBL
™
DOBUTAMINE HYDROCHLORIDE
INJECTION
_ _
Dobutamine Hydrochloride (_do-BEWT-a-meen)_
_ _
CONSUMER MEDICINE INFORMATION
_Date of Dispensing _
_Consumer Name _
_Pharmacist Name _
_Consumer Address _
_Pharmacist Address _
_ _
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about DBL
™
Dobutamine Hydrochloride
Injection.
It does not contain all the
available information.
It does not take the place of
talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has
weighed the risks of you being
given DBL
™
Dobutamine
Hydrochloride Injection against
the benefits they expect it will
have for you.
IF YOU HAVE ANY CONCERNS ABOUT
BEING GIVEN THIS MEDICINE, ASK
YOUR DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET IN A SAFE PLACE.
You may need to read it again.
WHAT DBL
™
DOBUTAMINE
HYDROCHLORIDE
INJECTION IS USED FOR
DBL
™
Dobutamine Hydrochloride
Injection is used in patients who
require short-term treatment of
heart failure following a heart
attack or heart surgery.
DBL
™
Dobutamine Hydrochloride
Injection acts directly on the heart
muscle to increase the force of
each contraction.
Your doctor may have prescribed
this medicine for another reason.
ASK YOUR DOCTOR IF YOU HAVE
ANY QUESTIONS ABOUT WHY DBL
™
DOBUTAMINE HYDROCHLORIDE
INJECTION HAS BEEN PRESCRIBED
FOR YOU.
There is no evidence that DBL
™
Dobutamine Hydrochloride
Injection is addictive.
This medicine is available only
with a doctor’s prescription.
BEFORE YOU ARE GIVEN
DBL
™
DOBUTAMINE
HYDROCHLORIDE
INJECTION
_WHEN YOU MUST NOT BE _
_GIVEN IT _
YOU MUST NOT BE GIVEN DBL
™
DOBUTAMINE HYDROCHLORIDE
INJECTION IF YOU HAVE AN ALLERGY
TO DOBUTAMINE OR ANY OF THE
INGREDIENTS LISTED AT THE END OF
THIS LEAFLET.
Symptoms of an alle
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产品特点
Product Information – Australia
Version 4.0
Page 1
DBL
™
DOBUTAMINE HYDROCHLORIDE INJECTION
NAME OF THE MEDICINE
Dobutamine hydrochloride
N
OH
.
HCl
CH
3
H
HO
HO
C
18
H
25
NO
3
.HCl
MW = 337.9, CAS REGISTRY NO: - 49745-95-1
(_RS_)-4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]-ethyl]
benzene-1,2-diol hydrochloride
DESCRIPTION
Dobutamine hydrochloride is a white to practically white, crystalline
powder. It is sparingly soluble in
water and methyl alcohol; soluble in alcohol. Dobutamine is
incompatible with alkaline solutions such
as sodium bicarbonate 5%.
DBL
™
Dobutamine Hydrochloride Injection is a sterile solution containing
in each 20 mL vial,
Dobutamine Hydrochloride USP 280.2 mg (250 mg Dobutamine equivalent)
and Sodium Metabisulfite
BP 4.4 mg.
PHARMACOLOGY
Dobutamine hydrochloride is an inotropic agent whose primary activity
results from stimulation of the
beta receptors of the heart while producing comparatively mild
chronotropic, hypertensive,
arrhythmogenic and vasodilative effects. The drug is believed to be a
direct agonist which, in animal
studies, produces less increase in heart rate and less decrease in
peripheral vascular resistance for a
given inotropic effect than does isoprenaline.
In patients with depressed cardiac function, both dobutamine and
isoprenaline increase the cardiac
output to a similar degree. In the case of dobutamine, this increase
is usually not accompanied by
marked increases in heart rate (although tachycardia is occasionally
observed), and the cardiac
stroke volume is usually increased. In contrast, isoprenaline
increases the cardiac index primarily by
increasing the heart rate while stroke volume changes little or
declines.
Facilitation of atrioventricular conduction has been observed in human
electrophysiologic studies in
normal subjects and in patients with atrial fibrillation.
Systemic vascular resistance is usually decr
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