País: Austrália
Língua: inglês
Origem: Department of Health (Therapeutic Goods Administration)
Dobutamine hydrochloride
Hospira Australia Pty Ltd
Medicine Listed (Export Only)
DBL ™ Dobutamine Hydrochloride Injection CMI Page 1 DBL ™ DOBUTAMINE HYDROCHLORIDE INJECTION _ _ Dobutamine Hydrochloride (_do-BEWT-a-meen)_ _ _ CONSUMER MEDICINE INFORMATION _Date of Dispensing _ _Consumer Name _ _Pharmacist Name _ _Consumer Address _ _Pharmacist Address _ _ _ WHAT IS IN THIS LEAFLET This leaflet answers some common questions about DBL ™ Dobutamine Hydrochloride Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you being given DBL ™ Dobutamine Hydrochloride Injection against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET IN A SAFE PLACE. You may need to read it again. WHAT DBL ™ DOBUTAMINE HYDROCHLORIDE INJECTION IS USED FOR DBL ™ Dobutamine Hydrochloride Injection is used in patients who require short-term treatment of heart failure following a heart attack or heart surgery. DBL ™ Dobutamine Hydrochloride Injection acts directly on the heart muscle to increase the force of each contraction. Your doctor may have prescribed this medicine for another reason. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY DBL ™ DOBUTAMINE HYDROCHLORIDE INJECTION HAS BEEN PRESCRIBED FOR YOU. There is no evidence that DBL ™ Dobutamine Hydrochloride Injection is addictive. This medicine is available only with a doctor’s prescription. BEFORE YOU ARE GIVEN DBL ™ DOBUTAMINE HYDROCHLORIDE INJECTION _WHEN YOU MUST NOT BE _ _GIVEN IT _ YOU MUST NOT BE GIVEN DBL ™ DOBUTAMINE HYDROCHLORIDE INJECTION IF YOU HAVE AN ALLERGY TO DOBUTAMINE OR ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. Symptoms of an alle Leia o documento completo
Product Information – Australia Version 4.0 Page 1 DBL ™ DOBUTAMINE HYDROCHLORIDE INJECTION NAME OF THE MEDICINE Dobutamine hydrochloride N OH . HCl CH 3 H HO HO C 18 H 25 NO 3 .HCl MW = 337.9, CAS REGISTRY NO: - 49745-95-1 (_RS_)-4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]-ethyl] benzene-1,2-diol hydrochloride DESCRIPTION Dobutamine hydrochloride is a white to practically white, crystalline powder. It is sparingly soluble in water and methyl alcohol; soluble in alcohol. Dobutamine is incompatible with alkaline solutions such as sodium bicarbonate 5%. DBL ™ Dobutamine Hydrochloride Injection is a sterile solution containing in each 20 mL vial, Dobutamine Hydrochloride USP 280.2 mg (250 mg Dobutamine equivalent) and Sodium Metabisulfite BP 4.4 mg. PHARMACOLOGY Dobutamine hydrochloride is an inotropic agent whose primary activity results from stimulation of the beta receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic and vasodilative effects. The drug is believed to be a direct agonist which, in animal studies, produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoprenaline. In patients with depressed cardiac function, both dobutamine and isoprenaline increase the cardiac output to a similar degree. In the case of dobutamine, this increase is usually not accompanied by marked increases in heart rate (although tachycardia is occasionally observed), and the cardiac stroke volume is usually increased. In contrast, isoprenaline increases the cardiac index primarily by increasing the heart rate while stroke volume changes little or declines. Facilitation of atrioventricular conduction has been observed in human electrophysiologic studies in normal subjects and in patients with atrial fibrillation. Systemic vascular resistance is usually decr Leia o documento completo