Coxidin® 200gkg MicroGranulate Premix

国家: 马来西亚

语言: 英文

来源: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有效成分:

MONENSIN SODIUM

可用日期:

PAHANG PHARMACY SDN. BHD.

INN（国际名称）:

MONENSIN SODIUM

每包单位数:

20 kg

厂商:

Biovet Joint Stock Company

产品特点

STATEMENT OF THE ACTIVE SUBSTANCE:
Monensin sodium 200 g/kg
PRODUCT DESCRIPTION:
®
Coxidin
200
g/kg
MicroGranulate
represents
granules of beige to brown colour intended for
administration through feed of poultry.
PHARMACODYNAMICS:
Monensin sodium acts as an ionophore, i.e. a
chemical substance that complexes monovalent
cations with the lipophilic structure that facilitates
the transport of the bound ion through biological
membranes. Coccidial sporozoites exposed to
monensin sodium in the intestinal lumen exhibit
considerable swelling, large vacuoles, pitting and
holes in the surface suggesting extreme osmotic
damage which is potentially lethal. Development
of a sporozoite that successfully invades a host
cell is inhibited as the ionophore continues its
destructive process. Monensin sodium selectively
destroys intracellular sporozoites while remaining
relatively non-injurious to the host cell. It has been
shown that monensin sodium has an effect on
second
generation
merozoites
but
not
upon
developing gametocytes.
PHARMACOKINETICS:
In the chicken monensin sodium is absorbed at a
limited extent. It is metabolized extensively and
gives
rise
to
demethylated,
oxidized
and
decarboxylated metabolites, found in the excreta
and tissues where they represent each less than
10%
of
the
total
monensin
derivatives.
The
proportion of unchanged monensin in the excreta
measured during a relatively short initial excretion
period (8 hrs) is 95% and 63% for the chicken and
turkey, respectively. The studies on monensin
residues in chicken and turkey show that the
highest contents are found in the skin plus fat then
the liver for both species and that their remanence
is very limited in all tissues (less than 24 hours).
Monensin
sodium
is
excreted
rapidly
mainly
through
the
faeces
with
considerable
biliary
excretion.
INDICATIONS FOR USE:
As an aid in the prevention of coccidiosis caused
by _Eimeria acervulina, E. brunetti, E. maxima, E. _
_mivati, _
_E. _
_necatrix _
and
_E. _
_tenella_
in
poultry
(broilers and replacement layers).
RECO